Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysis
Abstract Background Studies on the epidemiological information and prognosis of primary malignant lacrimal gland tumors (MLGTs) are rare for its low occurrence. The goal of our research was to investigate the epidemiological characteristics and survival outcomes of patients with MLGTs. Methods Incid...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6831 |
| _version_ | 1797216967884537856 |
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| author | Lin‐feng He Jin‐di Zhang Teng‐fei Zhu Peng‐cheng Zhao Pei Mou Shi‐yi Tang |
| author_facet | Lin‐feng He Jin‐di Zhang Teng‐fei Zhu Peng‐cheng Zhao Pei Mou Shi‐yi Tang |
| author_sort | Lin‐feng He |
| collection | DOAJ |
| description | Abstract Background Studies on the epidemiological information and prognosis of primary malignant lacrimal gland tumors (MLGTs) are rare for its low occurrence. The goal of our research was to investigate the epidemiological characteristics and survival outcomes of patients with MLGTs. Methods Incidence and demographic information of patients with MLGTs were collected from the Surveillance, Epidemiology, and End Results (SEER) database. To identify independent prognostic factors for disease‐specific survival (DSS) and overall survival (OS), univariate and multivariate Cox regression analysis were performed. Results The overall incidence of primary MLGTs from 1975 to 2020 was 0.413/1,000,000 (according to the 2000 American standard population), with a steadily increasing incidence over years. A total of 964 patients with primary MLGTs were diagnosed, with an average age of 59.3 years. Of these, 53.2% were aged ≥60 years, 57.4% were female, and 77.1% were whites. Multivariate Cox regression analysis demonstrated that year of diagnosis, age, sex, histological type, SEER stage, surgery, and chemotherapy were independent prognostic factors of DSS or OS. Conclusions Although primary MLGT is rare, its incidence has steadily increased in the past 46 years, and surgery was related to a better prognosis. |
| first_indexed | 2024-03-07T15:43:31Z |
| format | Article |
| id | doaj.art-5440063fa47c4e0c8463367a23cf6de5 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-24T11:54:23Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-5440063fa47c4e0c8463367a23cf6de52024-04-09T05:45:47ZengWileyCancer Medicine2045-76342024-02-01133n/an/a10.1002/cam4.6831Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysisLin‐feng He0Jin‐di Zhang1Teng‐fei Zhu2Peng‐cheng Zhao3Pei Mou4Shi‐yi Tang5Department of Ophthalmology Changzheng Hospital, Second Affiliated Hospital of Naval Medical University Shanghai ChinaDepartment of Ophthalmology Changzheng Hospital, Second Affiliated Hospital of Naval Medical University Shanghai ChinaDepartment of Anesthesiology Changzheng Hospital, Second Affiliated Hospital of Naval Medical University Shanghai ChinaDepartment of Anesthesiology Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Ophthalmology Changzheng Hospital, Second Affiliated Hospital of Naval Medical University Shanghai ChinaDepartment of Ophthalmology Gongli Hospital of Shanghai Pudong New Area Shanghai ChinaAbstract Background Studies on the epidemiological information and prognosis of primary malignant lacrimal gland tumors (MLGTs) are rare for its low occurrence. The goal of our research was to investigate the epidemiological characteristics and survival outcomes of patients with MLGTs. Methods Incidence and demographic information of patients with MLGTs were collected from the Surveillance, Epidemiology, and End Results (SEER) database. To identify independent prognostic factors for disease‐specific survival (DSS) and overall survival (OS), univariate and multivariate Cox regression analysis were performed. Results The overall incidence of primary MLGTs from 1975 to 2020 was 0.413/1,000,000 (according to the 2000 American standard population), with a steadily increasing incidence over years. A total of 964 patients with primary MLGTs were diagnosed, with an average age of 59.3 years. Of these, 53.2% were aged ≥60 years, 57.4% were female, and 77.1% were whites. Multivariate Cox regression analysis demonstrated that year of diagnosis, age, sex, histological type, SEER stage, surgery, and chemotherapy were independent prognostic factors of DSS or OS. Conclusions Although primary MLGT is rare, its incidence has steadily increased in the past 46 years, and surgery was related to a better prognosis.https://doi.org/10.1002/cam4.6831incidencelacrimal gland tumorsprognosisSEER |
| spellingShingle | Lin‐feng He Jin‐di Zhang Teng‐fei Zhu Peng‐cheng Zhao Pei Mou Shi‐yi Tang Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysis Cancer Medicine incidence lacrimal gland tumors prognosis SEER |
| title | Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysis |
| title_full | Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysis |
| title_fullStr | Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysis |
| title_full_unstemmed | Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysis |
| title_short | Incidence, clinical features, and survival outcomes of primary malignant lacrimal gland tumors: A population‐based analysis |
| title_sort | incidence clinical features and survival outcomes of primary malignant lacrimal gland tumors a population based analysis |
| topic | incidence lacrimal gland tumors prognosis SEER |
| url | https://doi.org/10.1002/cam4.6831 |
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