Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering
Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/12/4/386 |
| _version_ | 1797539099811250176 |
|---|---|
| author | Ana Rita M. P. Santos Yongjun Jang Inwoo Son Jongseong Kim Yongdoo Park |
| author_facet | Ana Rita M. P. Santos Yongjun Jang Inwoo Son Jongseong Kim Yongdoo Park |
| author_sort | Ana Rita M. P. Santos |
| collection | DOAJ |
| description | Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro requires integrating technologies of cardiac cells, biomaterials, fabrication, and computational modeling to model the complexity of heart tissue. Here, we review the recent progress of engineering techniques from simple to complex for fabricating matured cardiac tissue in vitro. Advancements in cardiomyocytes, extracellular matrix, geometry, and computational modeling will be discussed based on a technology perspective and their use for preparation of functional cardiac tissue. Since the heart is a very complex system at multiscale levels, an understanding of each technique and their interactions would be highly beneficial to the development of a fully functional heart in cardiac tissue engineering. |
| first_indexed | 2024-03-10T12:40:31Z |
| format | Article |
| id | doaj.art-5440485b9e3842dea548eee16f5bf71b |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T12:40:31Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-5440485b9e3842dea548eee16f5bf71b2023-11-21T13:53:44ZengMDPI AGMicromachines2072-666X2021-04-0112438610.3390/mi12040386Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex EngineeringAna Rita M. P. Santos0Yongjun Jang1Inwoo Son2Jongseong Kim3Yongdoo Park4BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, KoreaBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, KoreaBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, KoreaBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, KoreaBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, KoreaCardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro requires integrating technologies of cardiac cells, biomaterials, fabrication, and computational modeling to model the complexity of heart tissue. Here, we review the recent progress of engineering techniques from simple to complex for fabricating matured cardiac tissue in vitro. Advancements in cardiomyocytes, extracellular matrix, geometry, and computational modeling will be discussed based on a technology perspective and their use for preparation of functional cardiac tissue. Since the heart is a very complex system at multiscale levels, an understanding of each technique and their interactions would be highly beneficial to the development of a fully functional heart in cardiac tissue engineering.https://www.mdpi.com/2072-666X/12/4/386cardiac tissue engineeringhuman pluripotent stem cellcardiomyocytematurationextracellular matrixgeometry |
| spellingShingle | Ana Rita M. P. Santos Yongjun Jang Inwoo Son Jongseong Kim Yongdoo Park Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering Micromachines cardiac tissue engineering human pluripotent stem cell cardiomyocyte maturation extracellular matrix geometry |
| title | Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering |
| title_full | Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering |
| title_fullStr | Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering |
| title_full_unstemmed | Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering |
| title_short | Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering |
| title_sort | recapitulating cardiac structure and function in vitro from simple to complex engineering |
| topic | cardiac tissue engineering human pluripotent stem cell cardiomyocyte maturation extracellular matrix geometry |
| url | https://www.mdpi.com/2072-666X/12/4/386 |
| work_keys_str_mv | AT anaritampsantos recapitulatingcardiacstructureandfunctioninvitrofromsimpletocomplexengineering AT yongjunjang recapitulatingcardiacstructureandfunctioninvitrofromsimpletocomplexengineering AT inwooson recapitulatingcardiacstructureandfunctioninvitrofromsimpletocomplexengineering AT jongseongkim recapitulatingcardiacstructureandfunctioninvitrofromsimpletocomplexengineering AT yongdoopark recapitulatingcardiacstructureandfunctioninvitrofromsimpletocomplexengineering |