Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis

We describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good treatment responses and no cessation attributable to adverse effects. Bedaquiline could be considered for use with this age group for multidrug-r...

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Main Authors: Jay Achar, Cathy Hewison, Ana P. Cavalheiro, Alena Skrahina, Junia Cajazeiro, Parpieva Nargiza, Krzysztof Herboczek, Assliddin S. Rajabov, Jennifer Hughes, Gabriella Ferlazzo, James A. Seddon, Philipp du Cros
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2017-10-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/23/10/17-0303_article
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author Jay Achar
Cathy Hewison
Ana P. Cavalheiro
Alena Skrahina
Junia Cajazeiro
Parpieva Nargiza
Krzysztof Herboczek
Assliddin S. Rajabov
Jennifer Hughes
Gabriella Ferlazzo
James A. Seddon
Philipp du Cros
author_facet Jay Achar
Cathy Hewison
Ana P. Cavalheiro
Alena Skrahina
Junia Cajazeiro
Parpieva Nargiza
Krzysztof Herboczek
Assliddin S. Rajabov
Jennifer Hughes
Gabriella Ferlazzo
James A. Seddon
Philipp du Cros
author_sort Jay Achar
collection DOAJ
description We describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good treatment responses and no cessation attributable to adverse effects. Bedaquiline could be considered for use with this age group for multidrug-resistant tuberculosis when treatment options are limited.
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spelling doaj.art-544059b4ad5c40e8a553eb2fbb7268332022-12-21T23:46:08ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592017-10-0123101711171310.3201/eid2310.170303Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant TuberculosisJay AcharCathy HewisonAna P. CavalheiroAlena SkrahinaJunia CajazeiroParpieva NargizaKrzysztof HerboczekAssliddin S. RajabovJennifer HughesGabriella FerlazzoJames A. SeddonPhilipp du CrosWe describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good treatment responses and no cessation attributable to adverse effects. Bedaquiline could be considered for use with this age group for multidrug-resistant tuberculosis when treatment options are limited.https://wwwnc.cdc.gov/eid/article/23/10/17-0303_articleMDR TBXDR TBpediatrictreatmentbedaquilinetuberculosis
spellingShingle Jay Achar
Cathy Hewison
Ana P. Cavalheiro
Alena Skrahina
Junia Cajazeiro
Parpieva Nargiza
Krzysztof Herboczek
Assliddin S. Rajabov
Jennifer Hughes
Gabriella Ferlazzo
James A. Seddon
Philipp du Cros
Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis
Emerging Infectious Diseases
MDR TB
XDR TB
pediatric
treatment
bedaquiline
tuberculosis
title Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis
title_full Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis
title_fullStr Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis
title_full_unstemmed Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis
title_short Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis
title_sort off label use of bedaquiline in children and adolescents with multidrug resistant tuberculosis
topic MDR TB
XDR TB
pediatric
treatment
bedaquiline
tuberculosis
url https://wwwnc.cdc.gov/eid/article/23/10/17-0303_article
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