Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample
Abstract Background and aims Prevention measures for cardiovascular diseases (CVD) have shifted their focus from lipoproteins to the immune system. However, low-grade inflammation and dyslipidemia are tightly entangled. The objective of this study was to assess the relations between a broad panel of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01856-6 |
| _version_ | 1826913525585412096 |
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| author | Daniel L. Pontzen Martin Bahls Diana Albrecht Stephan B. Felix Marcus Dörr Till Ittermann Matthias Nauck Nele Friedrich |
| author_facet | Daniel L. Pontzen Martin Bahls Diana Albrecht Stephan B. Felix Marcus Dörr Till Ittermann Matthias Nauck Nele Friedrich |
| author_sort | Daniel L. Pontzen |
| collection | DOAJ |
| description | Abstract Background and aims Prevention measures for cardiovascular diseases (CVD) have shifted their focus from lipoproteins to the immune system. However, low-grade inflammation and dyslipidemia are tightly entangled. The objective of this study was to assess the relations between a broad panel of inflammatory biomarkers and lipoprotein subclass parameters. Methods We utilized data from the population-based Study of Health in Pomerania (SHIP-TREND, n = 403). Plasma concentrations of 37 inflammatory markers were measured by a bead-based assay. Furthermore, we employed nuclear magnetic resonance spectroscopy to measure total cholesterol, total triglycerides, total phospholipids as well as the fractional concentrations of cholesterol, triglycerides, phospholipids, ApoA1, ApoA2 and ApoB in all major lipoprotein subclasses. Associations between inflammatory biomarkers and lipoprotein subclasses were analyzed by adjusted linear regression models. Results APRIL, BAFF, TWEAK, sCD30, Pentraxin-3, sTNFR1, sTNFR2, Osteocalcin, Chitinase 3-like 1, IFN-alpha2, IFN-gamma, IL-11, IL-12p40, IL-29, IL-32, IL-35, TSLP, MMP1 and MMP2 were related with lipoprotein subclass components, forming two distinct clusters. APRIL had inverse relations to HDL-C (total and subclasses) and HDL Apo-A1 and Apo-A2 content. MMP-2 was inversely related to VLDL-C (total and subclasses), IDL-C as well as LDL5/6-C and VLDL-TG, IDL-TG, total triglycerides as well as LDL5/5-TG and HDL4-TG. Additionally, we identified a cluster of cytokines linked to the Th1-immune response, which were associated with an atherogenic lipoprotein profile. Conclusion Our findings expand the existing knowledge of inflammation-lipoprotein interactions, many of which are suggested to be involved in the pathogeneses of chronic non-communicable diseases. The results of our study support the use of immunomodulatory substances for the treatment and possibly prevention of CVD. |
| first_indexed | 2024-03-12T23:21:11Z |
| format | Article |
| id | doaj.art-5441a258140044e1b2a092c6f385d5d9 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2025-02-17T10:45:21Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-5441a258140044e1b2a092c6f385d5d92024-12-29T12:45:27ZengBMCLipids in Health and Disease1476-511X2023-07-0122111210.1186/s12944-023-01856-6Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sampleDaniel L. Pontzen0Martin Bahls1Diana Albrecht2Stephan B. Felix3Marcus Dörr4Till Ittermann5Matthias Nauck6Nele Friedrich7University Medicine GreifswaldUniversity Medicine GreifswaldInstitute for Community Medicine, SHIP-KEF, University Medicine GreifswaldUniversity Medicine GreifswaldUniversity Medicine GreifswaldGerman Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGerman Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGerman Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldAbstract Background and aims Prevention measures for cardiovascular diseases (CVD) have shifted their focus from lipoproteins to the immune system. However, low-grade inflammation and dyslipidemia are tightly entangled. The objective of this study was to assess the relations between a broad panel of inflammatory biomarkers and lipoprotein subclass parameters. Methods We utilized data from the population-based Study of Health in Pomerania (SHIP-TREND, n = 403). Plasma concentrations of 37 inflammatory markers were measured by a bead-based assay. Furthermore, we employed nuclear magnetic resonance spectroscopy to measure total cholesterol, total triglycerides, total phospholipids as well as the fractional concentrations of cholesterol, triglycerides, phospholipids, ApoA1, ApoA2 and ApoB in all major lipoprotein subclasses. Associations between inflammatory biomarkers and lipoprotein subclasses were analyzed by adjusted linear regression models. Results APRIL, BAFF, TWEAK, sCD30, Pentraxin-3, sTNFR1, sTNFR2, Osteocalcin, Chitinase 3-like 1, IFN-alpha2, IFN-gamma, IL-11, IL-12p40, IL-29, IL-32, IL-35, TSLP, MMP1 and MMP2 were related with lipoprotein subclass components, forming two distinct clusters. APRIL had inverse relations to HDL-C (total and subclasses) and HDL Apo-A1 and Apo-A2 content. MMP-2 was inversely related to VLDL-C (total and subclasses), IDL-C as well as LDL5/6-C and VLDL-TG, IDL-TG, total triglycerides as well as LDL5/5-TG and HDL4-TG. Additionally, we identified a cluster of cytokines linked to the Th1-immune response, which were associated with an atherogenic lipoprotein profile. Conclusion Our findings expand the existing knowledge of inflammation-lipoprotein interactions, many of which are suggested to be involved in the pathogeneses of chronic non-communicable diseases. The results of our study support the use of immunomodulatory substances for the treatment and possibly prevention of CVD.https://doi.org/10.1186/s12944-023-01856-6LipidomicsInflammationEpidemiologyPrevention of cardiovascular diseasesPrevention of metabolic diseasesChronic non-communicable diseases |
| spellingShingle | Daniel L. Pontzen Martin Bahls Diana Albrecht Stephan B. Felix Marcus Dörr Till Ittermann Matthias Nauck Nele Friedrich Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample Lipids in Health and Disease Lipidomics Inflammation Epidemiology Prevention of cardiovascular diseases Prevention of metabolic diseases Chronic non-communicable diseases |
| title | Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample |
| title_full | Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample |
| title_fullStr | Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample |
| title_full_unstemmed | Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample |
| title_short | Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample |
| title_sort | low grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample |
| topic | Lipidomics Inflammation Epidemiology Prevention of cardiovascular diseases Prevention of metabolic diseases Chronic non-communicable diseases |
| url | https://doi.org/10.1186/s12944-023-01856-6 |
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