Application of human amniotic epithelial cells in regenerative medicine: a systematic review
Abstract Human amniotic epithelial cells (hAECs) derived from placental tissues have gained considerable attention in the field of regenerative medicine. hAECs possess embryonic stem cell-like proliferation and differentiation capabilities, and adult stem cell-like immunomodulatory properties. Compa...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | http://link.springer.com/article/10.1186/s13287-020-01951-w |
| _version_ | 1819315570374344704 |
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| author | Qiuwan Zhang Dongmei Lai |
| author_facet | Qiuwan Zhang Dongmei Lai |
| author_sort | Qiuwan Zhang |
| collection | DOAJ |
| description | Abstract Human amniotic epithelial cells (hAECs) derived from placental tissues have gained considerable attention in the field of regenerative medicine. hAECs possess embryonic stem cell-like proliferation and differentiation capabilities, and adult stem cell-like immunomodulatory properties. Compared with other types of stem cell, hAECs have special advantages, including easy isolation, plentiful numbers, the obviation of ethical debates, and non-immunogenic and non-tumorigenic properties. During the past two decades, the therapeutic potential of hAECs for treatment of various diseases has been extensively investigated. Accumulating evidence has demonstrated that hAEC transplantation helps to repair and rebuild the function of damaged tissues and organs by different molecular mechanisms. This systematic review focused on summarizing the biological characteristics of hAECs, therapeutic applications, and recent advances in treating various tissue injuries and disorders. Relevant studies published in English from 2000 to 2020 describing the role of hAECs in diseases and phenotypes were comprehensively sought out using PubMed, MEDLINE, and Google Scholar. According to the research content, we described the major hAEC characteristics, including induced differentiation plasticity, homing and differentiation, paracrine function, and immunomodulatory properties. We also summarized the current status of clinical research and discussed the prospects of hAEC-based transplantation therapies. In this review, we provide a comprehensive understanding of the therapeutic potential of hAECs, including their use for cell replacement therapy as well as secreted cytokine and exosome biotherapy. Moreover, we showed that the powerful immune-regulatory function of hAECs reveals even more possibilities for their application in the treatment of immune-related diseases. In the future, establishing the optimal culture procedure, achieving precise and accurate treatment, and enhancing the therapeutic potential by utilizing appropriate preconditioning and/or biomaterials would be new challenges for further investigation. |
| first_indexed | 2024-12-24T10:02:12Z |
| format | Article |
| id | doaj.art-5442ed98a5bd4cc99195a6f1455ff188 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-24T10:02:12Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-5442ed98a5bd4cc99195a6f1455ff1882022-12-21T17:01:00ZengBMCStem Cell Research & Therapy1757-65122020-10-0111111610.1186/s13287-020-01951-wApplication of human amniotic epithelial cells in regenerative medicine: a systematic reviewQiuwan Zhang0Dongmei Lai1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Key Laboratory of Embryo Original Diseases; Shanghai Municipal Key Clinical SpecialityThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Key Laboratory of Embryo Original Diseases; Shanghai Municipal Key Clinical SpecialityAbstract Human amniotic epithelial cells (hAECs) derived from placental tissues have gained considerable attention in the field of regenerative medicine. hAECs possess embryonic stem cell-like proliferation and differentiation capabilities, and adult stem cell-like immunomodulatory properties. Compared with other types of stem cell, hAECs have special advantages, including easy isolation, plentiful numbers, the obviation of ethical debates, and non-immunogenic and non-tumorigenic properties. During the past two decades, the therapeutic potential of hAECs for treatment of various diseases has been extensively investigated. Accumulating evidence has demonstrated that hAEC transplantation helps to repair and rebuild the function of damaged tissues and organs by different molecular mechanisms. This systematic review focused on summarizing the biological characteristics of hAECs, therapeutic applications, and recent advances in treating various tissue injuries and disorders. Relevant studies published in English from 2000 to 2020 describing the role of hAECs in diseases and phenotypes were comprehensively sought out using PubMed, MEDLINE, and Google Scholar. According to the research content, we described the major hAEC characteristics, including induced differentiation plasticity, homing and differentiation, paracrine function, and immunomodulatory properties. We also summarized the current status of clinical research and discussed the prospects of hAEC-based transplantation therapies. In this review, we provide a comprehensive understanding of the therapeutic potential of hAECs, including their use for cell replacement therapy as well as secreted cytokine and exosome biotherapy. Moreover, we showed that the powerful immune-regulatory function of hAECs reveals even more possibilities for their application in the treatment of immune-related diseases. In the future, establishing the optimal culture procedure, achieving precise and accurate treatment, and enhancing the therapeutic potential by utilizing appropriate preconditioning and/or biomaterials would be new challenges for further investigation.http://link.springer.com/article/10.1186/s13287-020-01951-wHuman amniotic/amnion epithelial cellsCell transplantationDifferentiationParacrine propertiesImmunomodulationRegenerative medicine |
| spellingShingle | Qiuwan Zhang Dongmei Lai Application of human amniotic epithelial cells in regenerative medicine: a systematic review Stem Cell Research & Therapy Human amniotic/amnion epithelial cells Cell transplantation Differentiation Paracrine properties Immunomodulation Regenerative medicine |
| title | Application of human amniotic epithelial cells in regenerative medicine: a systematic review |
| title_full | Application of human amniotic epithelial cells in regenerative medicine: a systematic review |
| title_fullStr | Application of human amniotic epithelial cells in regenerative medicine: a systematic review |
| title_full_unstemmed | Application of human amniotic epithelial cells in regenerative medicine: a systematic review |
| title_short | Application of human amniotic epithelial cells in regenerative medicine: a systematic review |
| title_sort | application of human amniotic epithelial cells in regenerative medicine a systematic review |
| topic | Human amniotic/amnion epithelial cells Cell transplantation Differentiation Paracrine properties Immunomodulation Regenerative medicine |
| url | http://link.springer.com/article/10.1186/s13287-020-01951-w |
| work_keys_str_mv | AT qiuwanzhang applicationofhumanamnioticepithelialcellsinregenerativemedicineasystematicreview AT dongmeilai applicationofhumanamnioticepithelialcellsinregenerativemedicineasystematicreview |