Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s Disease
Hepatosplenic T-cell lymphoma (HSTCL) is an extremely rare and aggressive form of non-Hodgkin lymphoma associated with poor response to treatment and high mortality. There is an increased incidence among patients with inflammatory bowel disease, especially young male patients under 35 years old and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-11-01
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| Series: | GE: Portuguese Journal of Gastroenterology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/493350 |
| _version_ | 1819229627560755200 |
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| author | Joana Carvão Vítor Magno Pereira Fernando Jacinto Carla Sousa Andrade Luís Jasmins |
| author_facet | Joana Carvão Vítor Magno Pereira Fernando Jacinto Carla Sousa Andrade Luís Jasmins |
| author_sort | Joana Carvão |
| collection | DOAJ |
| description | Hepatosplenic T-cell lymphoma (HSTCL) is an extremely rare and aggressive form of non-Hodgkin lymphoma associated with poor response to treatment and high mortality. There is an increased incidence among patients with inflammatory bowel disease, especially young male patients under 35 years old and on combination therapy (thiopurine and anti-TNF-α). We describe a case of HSTCL in a young male patient with stenosing ileal Crohn’s disease on azathioprine monotherapy for 4.8 years admitted to our hospital with intra- abdominal sepsis. Despite chemotherapy, the patient eventually died 1 month after the diagnosis. Through a literature review, we identified 18 additional cases of HSTCL in Crohn’s disease patients that had only been treated with thiopurine monotherapy. The authors intend to highlight the rarity of this diagnosis especially with azathioprine monotherapy and the diagnostic challenge in a case that presented with intra-abdominal sepsis. |
| first_indexed | 2024-12-23T11:16:11Z |
| format | Article |
| id | doaj.art-54436726c48b487b8f5f19bc90452ccc |
| institution | Directory Open Access Journal |
| issn | 2341-4545 2387-1954 |
| language | English |
| last_indexed | 2024-12-23T11:16:11Z |
| publishDate | 2018-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | GE: Portuguese Journal of Gastroenterology |
| spelling | doaj.art-54436726c48b487b8f5f19bc90452ccc2022-12-21T17:49:13ZengKarger PublishersGE: Portuguese Journal of Gastroenterology2341-45452387-19542018-11-011610.1159/000493350493350Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s DiseaseJoana CarvãoVítor Magno PereiraFernando JacintoCarla Sousa AndradeLuís JasminsHepatosplenic T-cell lymphoma (HSTCL) is an extremely rare and aggressive form of non-Hodgkin lymphoma associated with poor response to treatment and high mortality. There is an increased incidence among patients with inflammatory bowel disease, especially young male patients under 35 years old and on combination therapy (thiopurine and anti-TNF-α). We describe a case of HSTCL in a young male patient with stenosing ileal Crohn’s disease on azathioprine monotherapy for 4.8 years admitted to our hospital with intra- abdominal sepsis. Despite chemotherapy, the patient eventually died 1 month after the diagnosis. Through a literature review, we identified 18 additional cases of HSTCL in Crohn’s disease patients that had only been treated with thiopurine monotherapy. The authors intend to highlight the rarity of this diagnosis especially with azathioprine monotherapy and the diagnostic challenge in a case that presented with intra-abdominal sepsis.https://www.karger.com/Article/FullText/493350Hepatosplenic T-cell lymphomaCrohn’s diseaseThiopurines |
| spellingShingle | Joana Carvão Vítor Magno Pereira Fernando Jacinto Carla Sousa Andrade Luís Jasmins Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s Disease GE: Portuguese Journal of Gastroenterology Hepatosplenic T-cell lymphoma Crohn’s disease Thiopurines |
| title | Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s Disease |
| title_full | Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s Disease |
| title_fullStr | Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s Disease |
| title_full_unstemmed | Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s Disease |
| title_short | Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s Disease |
| title_sort | hepatosplenic t cell lymphoma a rare complication of monotherapy with thiopurines in crohn s disease |
| topic | Hepatosplenic T-cell lymphoma Crohn’s disease Thiopurines |
| url | https://www.karger.com/Article/FullText/493350 |
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