Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process
A solvent-free and catalyst-free synthesis of fused bis-heterocycles containing imidazo[1,2-a]pyridine and tetrazolo[1,5-a]quinoline frameworks is reported via a one-pot process. This Groebke–Blackburn–Bienaymé reaction (GBBR)/SNAr/ring-chain azido tautomerization casc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Proceedings |
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| Online Access: | http://www.mdpi.com/2504-3900/9/1/41 |
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| author | Sandra C. Ramírez-López M. V. Basavanag Unnamatla Rocío Gámez-Montaño |
| author_facet | Sandra C. Ramírez-López M. V. Basavanag Unnamatla Rocío Gámez-Montaño |
| author_sort | Sandra C. Ramírez-López |
| collection | DOAJ |
| description | A solvent-free and catalyst-free synthesis of fused bis-heterocycles containing imidazo[1,2-a]pyridine and tetrazolo[1,5-a]quinoline frameworks is reported via a one-pot process. This Groebke–Blackburn–Bienaymé reaction (GBBR)/SNAr/ring-chain azido tautomerization cascade proceeds under eco-friendly conditions. The tetrazolo[1,5-a]quinoline and imidazo[1,2-a]pyridine scaffolds are present in various compounds with interesting pharmacological properties and could lead to the discovery of novel bioactive molecules. |
| first_indexed | 2024-04-12T21:51:49Z |
| format | Article |
| id | doaj.art-544455f294ad4fd4aa131c730dba2b49 |
| institution | Directory Open Access Journal |
| issn | 2504-3900 |
| language | English |
| last_indexed | 2024-04-12T21:51:49Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proceedings |
| spelling | doaj.art-544455f294ad4fd4aa131c730dba2b492022-12-22T03:15:27ZengMDPI AGProceedings2504-39002019-04-01914110.3390/ecsoc-22-05796ecsoc-22-05796Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot ProcessSandra C. Ramírez-López0M. V. Basavanag Unnamatla1Rocío Gámez-Montaño2Departamento de Química, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, C.P. 36050, Guanajuato, Gto., MexicoDepartamento de Química, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, C.P. 36050, Guanajuato, Gto., MexicoDepartamento de Química, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, C.P. 36050, Guanajuato, Gto., MexicoA solvent-free and catalyst-free synthesis of fused bis-heterocycles containing imidazo[1,2-a]pyridine and tetrazolo[1,5-a]quinoline frameworks is reported via a one-pot process. This Groebke–Blackburn–Bienaymé reaction (GBBR)/SNAr/ring-chain azido tautomerization cascade proceeds under eco-friendly conditions. The tetrazolo[1,5-a]quinoline and imidazo[1,2-a]pyridine scaffolds are present in various compounds with interesting pharmacological properties and could lead to the discovery of novel bioactive molecules.http://www.mdpi.com/2504-3900/9/1/41isocyanide-based multicomponent reactionsGroebke–Blackburn–Bienaymé reactiontetrazolo[1,5-a]quinolinesring-chain azido tautomerizationone-pot process |
| spellingShingle | Sandra C. Ramírez-López M. V. Basavanag Unnamatla Rocío Gámez-Montaño Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process Proceedings isocyanide-based multicomponent reactions Groebke–Blackburn–Bienaymé reaction tetrazolo[1,5-a]quinolines ring-chain azido tautomerization one-pot process |
| title | Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process |
| title_full | Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process |
| title_fullStr | Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process |
| title_full_unstemmed | Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process |
| title_short | Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process |
| title_sort | solvent free synthesis of imidazo 1 2 a pyridin tetrazolo 1 5 a quinolines via an imcr one pot process |
| topic | isocyanide-based multicomponent reactions Groebke–Blackburn–Bienaymé reaction tetrazolo[1,5-a]quinolines ring-chain azido tautomerization one-pot process |
| url | http://www.mdpi.com/2504-3900/9/1/41 |
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