Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis

Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis

In the process of generating presumably clonal human induced pluripotent stem cells (hiPSCs) from two carriers of a complex structural rearrangement, each having a psychotic disorder, we also serendipitously generated isogenic non-carrier control hiPSCs, finding that the rearrangement occurs as an e...

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Bibliographic Details
Main Authors: Julia TCW, Claudia M.B. Carvalho, Bo Yuan, Shen Gu, Alyssa N. Altheimer, Shane McCarthy, Dheeraj Malhotra, Jonathan Sebat, Arthur J. Siegel, Uwe Rudolph, James R. Lupski, Deborah L. Levy, Kristen J. Brennand
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Stem Cell Reports
Subjects:
9p24.1
marker chromosome
human induced pluripotent stem cell
neural progenitor cell
schizophrenia
bipolar disorder
isogenic
mosaic
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117300255

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