Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct
BackgroundDespite the development of a new class of antiemetics, postoperative nausea and vomiting (PONV) still remains a frequent and distressing complication. We compared the prophylactic antiemetic effect of administering dexamethasone 5 mg as an adjunct to ramosetron and ondansetron in patients...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2012-06-01
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| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kjae-62-543.pdf |
| _version_ | 1818324913667178496 |
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| author | Yong Seon Choi Jae-Kwang Shim Seung-Ho Ahn Young Lan Kwak |
| author_facet | Yong Seon Choi Jae-Kwang Shim Seung-Ho Ahn Young Lan Kwak |
| author_sort | Yong Seon Choi |
| collection | DOAJ |
| description | BackgroundDespite the development of a new class of antiemetics, postoperative nausea and vomiting (PONV) still remains a frequent and distressing complication. We compared the prophylactic antiemetic effect of administering dexamethasone 5 mg as an adjunct to ramosetron and ondansetron in patients at high-risk for PONV following lumbar spinal surgery.MethodsIn this randomized, double-blind study, 120 female non-smoking patients with intravenous patient-controlled analgesia (PCA) received ramosetron 0.3 mg plus dexamethasone 5 mg (group R + D) or ondansetron 4 mg plus dexamethasone 5 mg (group O + D) intravenously. Fentanyl-based PCA was administered for 48 hr postoperatively; ramosetron 0.3 mg or ondansetron 12 mg was added to the PCA regimen according to the allocated group. The incidence of PONV and rescue antiemetic were assessed for 48 hr postoperatively at 0-6, 6-24, and 24-48 hr.ResultsThe overall incidence of PONV did not differ between the groups (50% vs. 60%, in groups R + D and O + D, respectively). The overall incidence of nausea was similar between groups (47% vs. 60%, in groups R + D and O + D, respectively). The overall frequency of vomiting was also similar between groups (8% vs. 12%, in groups R + D and O + D, respectively). The severity of nausea and the overall use of rescue antiemetic were not different between groups.ConclusionsThe antiemetic efficacy of ramosetron plus dexamethasone was similar to that of ondansetron plus dexamethasone on preventing PONV in high-risk patients undergoing lumbar spinal surgery. |
| first_indexed | 2024-12-13T11:36:09Z |
| format | Article |
| id | doaj.art-54476ce63b5f40feb53c72a0a8e79eb1 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-13T11:36:09Z |
| publishDate | 2012-06-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-54476ce63b5f40feb53c72a0a8e79eb12022-12-21T23:47:47ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632012-06-0162654354710.4097/kjae.2012.62.6.5437358Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunctYong Seon Choi0Jae-Kwang Shim1Seung-Ho Ahn2Young Lan Kwak3Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.BackgroundDespite the development of a new class of antiemetics, postoperative nausea and vomiting (PONV) still remains a frequent and distressing complication. We compared the prophylactic antiemetic effect of administering dexamethasone 5 mg as an adjunct to ramosetron and ondansetron in patients at high-risk for PONV following lumbar spinal surgery.MethodsIn this randomized, double-blind study, 120 female non-smoking patients with intravenous patient-controlled analgesia (PCA) received ramosetron 0.3 mg plus dexamethasone 5 mg (group R + D) or ondansetron 4 mg plus dexamethasone 5 mg (group O + D) intravenously. Fentanyl-based PCA was administered for 48 hr postoperatively; ramosetron 0.3 mg or ondansetron 12 mg was added to the PCA regimen according to the allocated group. The incidence of PONV and rescue antiemetic were assessed for 48 hr postoperatively at 0-6, 6-24, and 24-48 hr.ResultsThe overall incidence of PONV did not differ between the groups (50% vs. 60%, in groups R + D and O + D, respectively). The overall incidence of nausea was similar between groups (47% vs. 60%, in groups R + D and O + D, respectively). The overall frequency of vomiting was also similar between groups (8% vs. 12%, in groups R + D and O + D, respectively). The severity of nausea and the overall use of rescue antiemetic were not different between groups.ConclusionsThe antiemetic efficacy of ramosetron plus dexamethasone was similar to that of ondansetron plus dexamethasone on preventing PONV in high-risk patients undergoing lumbar spinal surgery.http://ekja.org/upload/pdf/kjae-62-543.pdfdexamethasoneondansetronpostoperative nausea and vomitingramosetron |
| spellingShingle | Yong Seon Choi Jae-Kwang Shim Seung-Ho Ahn Young Lan Kwak Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct Korean Journal of Anesthesiology dexamethasone ondansetron postoperative nausea and vomiting ramosetron |
| title | Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct |
| title_full | Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct |
| title_fullStr | Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct |
| title_full_unstemmed | Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct |
| title_short | Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct |
| title_sort | efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high risk patients following spine surgery with a single bolus of dexamethasone as an adjunct |
| topic | dexamethasone ondansetron postoperative nausea and vomiting ramosetron |
| url | http://ekja.org/upload/pdf/kjae-62-543.pdf |
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