Metformin in the treatment of breast cancer among patients with metabolic syndrome
Breast cancer (BC) is one of the most common cancer among women worldwide. In 2005, the International Diabetes Federation (International Diabetes Federation) declared metabolic syndrome is one of the main problems of modern medicine, as it increases the total mortality and the prevalence has reached...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-11-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/454 |
| _version_ | 1826557271289626624 |
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| author | R. V. Lyubota |
| author_facet | R. V. Lyubota |
| author_sort | R. V. Lyubota |
| collection | DOAJ |
| description | Breast cancer (BC) is one of the most common cancer among women worldwide. In 2005, the International Diabetes Federation (International Diabetes Federation) declared metabolic syndrome is one of the main problems of modern medicine, as it increases the total mortality and the prevalence has reached pandemic levels. Several studies have shown that the metabolic disorders associated with metabolic syndrome, affect the carcinogenesis of BC. Improving the efficiency of chemotherapy in patients with type 2 diabetes taking biguanides compared with patients who used other hypoglycemic agents, it has become a premise for the study of the possible antitumor mechanism of action of metformin. Therefore, adequate correction of metabolic disturbances caused by metabolic syndrome may be an additional area of special treatment, as well as a measure of primary and secondary prevention of BC. Improving the efficiency of tumor therapy in patientswith type 2 diabetes taking biguanides compared with patients who used other hypoglycemic agents, it has become a prerequisite for the study of the possible antitumor mechanism of action of metformin. This paper presents the results of studying the effect of metformin on the effectiveness of neoadjuvant systemic therapy for BC patients with the metabolic syndrome. |
| first_indexed | 2024-04-10T01:56:23Z |
| format | Article |
| id | doaj.art-544886986e804b8fa1de604842b6da32 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2025-03-14T08:25:57Z |
| publishDate | 2015-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-544886986e804b8fa1de604842b6da322025-03-02T13:05:33ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272015-11-01114182410.17650/1994-4098-2015-11-4-18-24467Metformin in the treatment of breast cancer among patients with metabolic syndromeR. V. Lyubota0A. A. Bogomolets National Medical University; 13 T. Shevchenko Byl’var, Kiev, 01601, UkraineBreast cancer (BC) is one of the most common cancer among women worldwide. In 2005, the International Diabetes Federation (International Diabetes Federation) declared metabolic syndrome is one of the main problems of modern medicine, as it increases the total mortality and the prevalence has reached pandemic levels. Several studies have shown that the metabolic disorders associated with metabolic syndrome, affect the carcinogenesis of BC. Improving the efficiency of chemotherapy in patients with type 2 diabetes taking biguanides compared with patients who used other hypoglycemic agents, it has become a premise for the study of the possible antitumor mechanism of action of metformin. Therefore, adequate correction of metabolic disturbances caused by metabolic syndrome may be an additional area of special treatment, as well as a measure of primary and secondary prevention of BC. Improving the efficiency of tumor therapy in patientswith type 2 diabetes taking biguanides compared with patients who used other hypoglycemic agents, it has become a prerequisite for the study of the possible antitumor mechanism of action of metformin. This paper presents the results of studying the effect of metformin on the effectiveness of neoadjuvant systemic therapy for BC patients with the metabolic syndrome.https://ojrs.abvpress.ru/ojrs/article/view/454breast cancermetabolic syndromeobesitybiguanidesmetforminneoadjuvant systemic antitumor therapyhormonal therapychemotherapyefficiency |
| spellingShingle | R. V. Lyubota Metformin in the treatment of breast cancer among patients with metabolic syndrome Опухоли женской репродуктивной системы breast cancer metabolic syndrome obesity biguanides metformin neoadjuvant systemic antitumor therapy hormonal therapy chemotherapy efficiency |
| title | Metformin in the treatment of breast cancer among patients with metabolic syndrome |
| title_full | Metformin in the treatment of breast cancer among patients with metabolic syndrome |
| title_fullStr | Metformin in the treatment of breast cancer among patients with metabolic syndrome |
| title_full_unstemmed | Metformin in the treatment of breast cancer among patients with metabolic syndrome |
| title_short | Metformin in the treatment of breast cancer among patients with metabolic syndrome |
| title_sort | metformin in the treatment of breast cancer among patients with metabolic syndrome |
| topic | breast cancer metabolic syndrome obesity biguanides metformin neoadjuvant systemic antitumor therapy hormonal therapy chemotherapy efficiency |
| url | https://ojrs.abvpress.ru/ojrs/article/view/454 |
| work_keys_str_mv | AT rvlyubota metformininthetreatmentofbreastcanceramongpatientswithmetabolicsyndrome |