Assessing Cognitive Abilities of Patients With Shift Work Disorder: Insights From RBANS and Granger Causality Connections Among Resting-State Networks
BackgroundNumerous studies have confirmed that long-term shift work is not only associated with increased health problems and acute impact on safety but also with impaired cognitive abilities. However, very little is known about effects of shift work on cognition-related brain resting-state networks...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00780/full |
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| author | Yanzhe Ning Kuangshi Li Yong Zhang Pei Chen Dongqing Yin Hong Zhu Hongxiao Jia |
| author_facet | Yanzhe Ning Kuangshi Li Yong Zhang Pei Chen Dongqing Yin Hong Zhu Hongxiao Jia |
| author_sort | Yanzhe Ning |
| collection | DOAJ |
| description | BackgroundNumerous studies have confirmed that long-term shift work is not only associated with increased health problems and acute impact on safety but also with impaired cognitive abilities. However, very little is known about effects of shift work on cognition-related brain resting-state networks. The aim of this study was to explore the effects of shift work disorder (SWD) on granger causality connection among resting-state brain networks.MethodsThirty patients with SWD and 25 matched healthy subjects were recruited to undergo the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and resting-state fMRI scanning. We employed independent component analysis (ICA) to extract resting-state brain networks and granger causality analysis (GCA) to characterize the difference of granger causality connection among cognition-related resting-state brain networks.ResultsCompared with healthy subjects, patients with SWD showed impairments on the attention and immediate memory. Seven resting-state brain networks were identified, and patients with SWD showed more numerous granger causality connections in comparison with healthy subjects. Two-sample t test results showed that there were significantly increased inflows from the anterior default mode network (aDMN) to sensorimotor network (SMN) and left frontoparietal network (LFPN) to salience network (SN). Correlation analyses showed that the increased inflows from aDMN to SMN were negatively associated with the score of attention, while LFPN to SN were negatively associated with the score of visuospatial/constructional ability.ConclusionsThis study indicates that SWD impairs cognitive performance, and the specific intrinsic brain granger causality connectivity among resting-state networks in SWD patients is affected after long-term shift works. |
| first_indexed | 2024-12-21T03:06:17Z |
| format | Article |
| id | doaj.art-544968779d4f41ac99d5706483174d29 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-21T03:06:17Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-544968779d4f41ac99d5706483174d292022-12-21T19:18:05ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-08-011110.3389/fpsyt.2020.00780563584Assessing Cognitive Abilities of Patients With Shift Work Disorder: Insights From RBANS and Granger Causality Connections Among Resting-State NetworksYanzhe Ning0Kuangshi Li1Yong Zhang2Pei Chen3Dongqing Yin4Hong Zhu5Hongxiao Jia6The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaDepartment of Rehabilitation, Dongzhimen Hospital, The First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Rehabilitation, Dongzhimen Hospital, The First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaBackgroundNumerous studies have confirmed that long-term shift work is not only associated with increased health problems and acute impact on safety but also with impaired cognitive abilities. However, very little is known about effects of shift work on cognition-related brain resting-state networks. The aim of this study was to explore the effects of shift work disorder (SWD) on granger causality connection among resting-state brain networks.MethodsThirty patients with SWD and 25 matched healthy subjects were recruited to undergo the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and resting-state fMRI scanning. We employed independent component analysis (ICA) to extract resting-state brain networks and granger causality analysis (GCA) to characterize the difference of granger causality connection among cognition-related resting-state brain networks.ResultsCompared with healthy subjects, patients with SWD showed impairments on the attention and immediate memory. Seven resting-state brain networks were identified, and patients with SWD showed more numerous granger causality connections in comparison with healthy subjects. Two-sample t test results showed that there were significantly increased inflows from the anterior default mode network (aDMN) to sensorimotor network (SMN) and left frontoparietal network (LFPN) to salience network (SN). Correlation analyses showed that the increased inflows from aDMN to SMN were negatively associated with the score of attention, while LFPN to SN were negatively associated with the score of visuospatial/constructional ability.ConclusionsThis study indicates that SWD impairs cognitive performance, and the specific intrinsic brain granger causality connectivity among resting-state networks in SWD patients is affected after long-term shift works.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00780/fullgranger causality connectionresting-state functional magnetic resonance imagingresting-state networksshift work disordercognitive abilities |
| spellingShingle | Yanzhe Ning Kuangshi Li Yong Zhang Pei Chen Dongqing Yin Hong Zhu Hongxiao Jia Assessing Cognitive Abilities of Patients With Shift Work Disorder: Insights From RBANS and Granger Causality Connections Among Resting-State Networks Frontiers in Psychiatry granger causality connection resting-state functional magnetic resonance imaging resting-state networks shift work disorder cognitive abilities |
| title | Assessing Cognitive Abilities of Patients With Shift Work Disorder: Insights From RBANS and Granger Causality Connections Among Resting-State Networks |
| title_full | Assessing Cognitive Abilities of Patients With Shift Work Disorder: Insights From RBANS and Granger Causality Connections Among Resting-State Networks |
| title_fullStr | Assessing Cognitive Abilities of Patients With Shift Work Disorder: Insights From RBANS and Granger Causality Connections Among Resting-State Networks |
| title_full_unstemmed | Assessing Cognitive Abilities of Patients With Shift Work Disorder: Insights From RBANS and Granger Causality Connections Among Resting-State Networks |
| title_short | Assessing Cognitive Abilities of Patients With Shift Work Disorder: Insights From RBANS and Granger Causality Connections Among Resting-State Networks |
| title_sort | assessing cognitive abilities of patients with shift work disorder insights from rbans and granger causality connections among resting state networks |
| topic | granger causality connection resting-state functional magnetic resonance imaging resting-state networks shift work disorder cognitive abilities |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00780/full |
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