Progress of nucleic acid drugs and non-viral carriers in gene therapy
Gene therapy based on nucleic acid drugs is the ultimate treatment technology for gene abnormality related diseases. However, nucleic acid drugs need the help of carriers to enter target cells and reach specific intracellular locations, therefore, the development of safe and efficient delivery syste...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-01-01
|
| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-1-41.pdf |
| _version_ | 1797365916748480512 |
|---|---|
| author | LIU Jian |
| author_facet | LIU Jian |
| author_sort | LIU Jian |
| collection | DOAJ |
| description | Gene therapy based on nucleic acid drugs is the ultimate treatment technology for gene abnormality related diseases. However, nucleic acid drugs need the help of carriers to enter target cells and reach specific intracellular locations, therefore, the development of safe and efficient delivery systems for nucleic acid drugs is one of the fundamental technologies for gene therapy. Compared with viral vectors, non-viral vectors have higher safety, but are still facing the challenge of relative low transfection efficiency. With the advances of nanotechnology, the efficiency of non-viral carriers has been gained significantly improvements. In this paper, some representative nucleic acid-based drugs and vaccines are introduced, and the progresses of non-viral delivery carriers for uses in gene therapy have been reviewed. |
| first_indexed | 2024-03-08T16:55:46Z |
| format | Article |
| id | doaj.art-544b26bdec8d4bdba07403244ec554b3 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:55:46Z |
| publishDate | 2022-01-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-544b26bdec8d4bdba07403244ec554b32024-01-05T02:33:55ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-01-01421415010.16352/j.issn.1001-6325.2022.01.002Progress of nucleic acid drugs and non-viral carriers in gene therapyLIU Jian0Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, ChinaGene therapy based on nucleic acid drugs is the ultimate treatment technology for gene abnormality related diseases. However, nucleic acid drugs need the help of carriers to enter target cells and reach specific intracellular locations, therefore, the development of safe and efficient delivery systems for nucleic acid drugs is one of the fundamental technologies for gene therapy. Compared with viral vectors, non-viral vectors have higher safety, but are still facing the challenge of relative low transfection efficiency. With the advances of nanotechnology, the efficiency of non-viral carriers has been gained significantly improvements. In this paper, some representative nucleic acid-based drugs and vaccines are introduced, and the progresses of non-viral delivery carriers for uses in gene therapy have been reviewed.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-1-41.pdfgene therapy|nucleic acid drugs|non-viral carrier|drug delivery system |
| spellingShingle | LIU Jian Progress of nucleic acid drugs and non-viral carriers in gene therapy Jichu yixue yu linchuang gene therapy|nucleic acid drugs|non-viral carrier|drug delivery system |
| title | Progress of nucleic acid drugs and non-viral carriers in gene therapy |
| title_full | Progress of nucleic acid drugs and non-viral carriers in gene therapy |
| title_fullStr | Progress of nucleic acid drugs and non-viral carriers in gene therapy |
| title_full_unstemmed | Progress of nucleic acid drugs and non-viral carriers in gene therapy |
| title_short | Progress of nucleic acid drugs and non-viral carriers in gene therapy |
| title_sort | progress of nucleic acid drugs and non viral carriers in gene therapy |
| topic | gene therapy|nucleic acid drugs|non-viral carrier|drug delivery system |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-1-41.pdf |
| work_keys_str_mv | AT liujian progressofnucleicaciddrugsandnonviralcarriersingenetherapy |