Stability and Antiglycoxidant Potential of Bilberry Anthocyanins in Simulated Gastrointestinal Tract Model
Anthocyanins from <i>Vaccinium myrtillus</i> fruits have been reported in vitro to exert potent radical scavenging and antiglycation activities. However, the physiological relevance of such properties remains unclear given the potential susceptibility of anthocyanin derivatives to digest...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/9/11/1695 |
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| author | Didier Fraisse Alexis Bred Catherine Felgines François Senejoux |
| author_facet | Didier Fraisse Alexis Bred Catherine Felgines François Senejoux |
| author_sort | Didier Fraisse |
| collection | DOAJ |
| description | Anthocyanins from <i>Vaccinium myrtillus</i> fruits have been reported in vitro to exert potent radical scavenging and antiglycation activities. However, the physiological relevance of such properties remains unclear given the potential susceptibility of anthocyanin derivatives to digestive conditions. A simulated gastrointestinal tract model was thus implemented to assess the impact of gastric and intestinal phases on the chemical integrity of bilberry anthocyanins and their antiglycoxidant effects. Results demonstrated that the investigated activities as well as total and individual anthocyanin contents were marginally affected by gastric conditions. By contrast, with recoveries ranging from 16.1 to 41.2%, bilberry anthocyanins were shown to be highly sensitive to the intestinal phase. Of major interest, a much better preservation was observed for radical scavenging and antiglycation activities as attested by recovery rates ranging from 79.1 to 86.7%. Consistently with previous observations, the present study confirms the moderate bioaccessibility of anthocyanin constituents. It does however provide valuable information supporting the persistence of substantial radical scavenging and antiglycation activities at each step of the digestion process. Taken together, these data indicate that digestive conditions might not abolish the potential positive effects of bilberry consumption on both oxidative and carbonyl stresses. |
| first_indexed | 2024-03-10T14:43:46Z |
| format | Article |
| id | doaj.art-544bb8a694244a2caf1383509689dc4e |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T14:43:46Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-544bb8a694244a2caf1383509689dc4e2023-11-20T21:31:51ZengMDPI AGFoods2304-81582020-11-01911169510.3390/foods9111695Stability and Antiglycoxidant Potential of Bilberry Anthocyanins in Simulated Gastrointestinal Tract ModelDidier Fraisse0Alexis Bred1Catherine Felgines2François Senejoux3Unité de Nutrition Humaine, Université Clermont-Auvergne, INRA, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUnité de Nutrition Humaine, Université Clermont-Auvergne, INRA, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUnité de Nutrition Humaine, Université Clermont-Auvergne, INRA, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceUnité de Nutrition Humaine, Université Clermont-Auvergne, INRA, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, FranceAnthocyanins from <i>Vaccinium myrtillus</i> fruits have been reported in vitro to exert potent radical scavenging and antiglycation activities. However, the physiological relevance of such properties remains unclear given the potential susceptibility of anthocyanin derivatives to digestive conditions. A simulated gastrointestinal tract model was thus implemented to assess the impact of gastric and intestinal phases on the chemical integrity of bilberry anthocyanins and their antiglycoxidant effects. Results demonstrated that the investigated activities as well as total and individual anthocyanin contents were marginally affected by gastric conditions. By contrast, with recoveries ranging from 16.1 to 41.2%, bilberry anthocyanins were shown to be highly sensitive to the intestinal phase. Of major interest, a much better preservation was observed for radical scavenging and antiglycation activities as attested by recovery rates ranging from 79.1 to 86.7%. Consistently with previous observations, the present study confirms the moderate bioaccessibility of anthocyanin constituents. It does however provide valuable information supporting the persistence of substantial radical scavenging and antiglycation activities at each step of the digestion process. Taken together, these data indicate that digestive conditions might not abolish the potential positive effects of bilberry consumption on both oxidative and carbonyl stresses.https://www.mdpi.com/2304-8158/9/11/1695bilberryanthocyanindigestionantioxidantglycationbioaccessibility |
| spellingShingle | Didier Fraisse Alexis Bred Catherine Felgines François Senejoux Stability and Antiglycoxidant Potential of Bilberry Anthocyanins in Simulated Gastrointestinal Tract Model Foods bilberry anthocyanin digestion antioxidant glycation bioaccessibility |
| title | Stability and Antiglycoxidant Potential of Bilberry Anthocyanins in Simulated Gastrointestinal Tract Model |
| title_full | Stability and Antiglycoxidant Potential of Bilberry Anthocyanins in Simulated Gastrointestinal Tract Model |
| title_fullStr | Stability and Antiglycoxidant Potential of Bilberry Anthocyanins in Simulated Gastrointestinal Tract Model |
| title_full_unstemmed | Stability and Antiglycoxidant Potential of Bilberry Anthocyanins in Simulated Gastrointestinal Tract Model |
| title_short | Stability and Antiglycoxidant Potential of Bilberry Anthocyanins in Simulated Gastrointestinal Tract Model |
| title_sort | stability and antiglycoxidant potential of bilberry anthocyanins in simulated gastrointestinal tract model |
| topic | bilberry anthocyanin digestion antioxidant glycation bioaccessibility |
| url | https://www.mdpi.com/2304-8158/9/11/1695 |
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