Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer

Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer

Abstract Background Enhanced glucose metabolism is a feature of most tumors, but downstream functional effects of aberrant glucose flux are difficult to mechanistically determine. Metabolic diseases including obesity and diabetes have a hyperglycemia component and are correlated with elevated pre-me...

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Bibliographic Details
Main Authors: Saheed A. Ayodeji, Bin Bao, Emily A. Teslow, Lisa A. Polin, Greg Dyson, Aliccia Bollig-Fischer, Charlie Fehl
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cancer Cell International
Subjects:
O-GlcNAc transferase
Hyperglycemia
TNBC
Tumorigenesis
Metabolic disease
Glycobiology
Online Access:https://doi.org/10.1186/s12935-023-02942-6

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