Oncological Applications of Photodynamic Therapy in Dogs and Cats
Photodynamic therapy (PDT) in small animals’ oncology has been under research focus, pointing to new treatment possibilities. Moreover, several animal studies constitute experimental human disease models due to the similarity of tumor biology between animals and man. PDT uses photosensitizing compou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/23/12276 |
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| author | Tarcísio Guerra Guimarães Karla Menezes Cardoso Carlos Miguel Marto Ricardo Teixo Beatriz Serambeque Fernando Capela e Silva Nuno Alexandre Maria Filomena Botelho Mafalda Laranjo |
| author_facet | Tarcísio Guerra Guimarães Karla Menezes Cardoso Carlos Miguel Marto Ricardo Teixo Beatriz Serambeque Fernando Capela e Silva Nuno Alexandre Maria Filomena Botelho Mafalda Laranjo |
| author_sort | Tarcísio Guerra Guimarães |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) in small animals’ oncology has been under research focus, pointing to new treatment possibilities. Moreover, several animal studies constitute experimental human disease models due to the similarity of tumor biology between animals and man. PDT uses photosensitizing compounds without toxicity per se. When subjected to a specific wavelength, the photosensitizers are activated, triggering the production of reactive oxygen species (ROS) that lead to cell death. Additionally, antiangiogenic effects and immune stimulation may also be elicited. PDT is minimally invasive, non-toxic, and does not induce carcinogenic or mutagenic side effects. Thus, it is safe for non-neoplastic tissues compared with other neoplasms treatment modalities. This review describes the applications of PDT in the cancer treatment of small animals, particularly dogs and cats, focusing on the respective photosensitizers and treatment protocols used in trials in this therapeutic modality. |
| first_indexed | 2024-03-09T17:53:10Z |
| format | Article |
| id | doaj.art-544e5d4e33364fa5a2b9a4393562ddd7 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T17:53:10Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-544e5d4e33364fa5a2b9a4393562ddd72023-11-24T10:33:52ZengMDPI AGApplied Sciences2076-34172022-11-0112231227610.3390/app122312276Oncological Applications of Photodynamic Therapy in Dogs and CatsTarcísio Guerra Guimarães0Karla Menezes Cardoso1Carlos Miguel Marto2Ricardo Teixo3Beatriz Serambeque4Fernando Capela e Silva5Nuno Alexandre6Maria Filomena Botelho7Mafalda Laranjo8Institute for Advanced Studies and Research (IIFA), University of Évora, 7002-554 Évora, PortugalInstitute for Advanced Studies and Research (IIFA), University of Évora, 7002-554 Évora, PortugalInstitute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, PortugalInstitute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, PortugalInstitute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, PortugalMediterranean Institute for Agriculture, Environment and Development (MED) and Global Change and Sustainability Institute (CHANGE), 7006-554 Évora, PortugalMediterranean Institute for Agriculture, Environment and Development (MED) and Global Change and Sustainability Institute (CHANGE), 7006-554 Évora, PortugalInstitute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, PortugalInstitute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, PortugalPhotodynamic therapy (PDT) in small animals’ oncology has been under research focus, pointing to new treatment possibilities. Moreover, several animal studies constitute experimental human disease models due to the similarity of tumor biology between animals and man. PDT uses photosensitizing compounds without toxicity per se. When subjected to a specific wavelength, the photosensitizers are activated, triggering the production of reactive oxygen species (ROS) that lead to cell death. Additionally, antiangiogenic effects and immune stimulation may also be elicited. PDT is minimally invasive, non-toxic, and does not induce carcinogenic or mutagenic side effects. Thus, it is safe for non-neoplastic tissues compared with other neoplasms treatment modalities. This review describes the applications of PDT in the cancer treatment of small animals, particularly dogs and cats, focusing on the respective photosensitizers and treatment protocols used in trials in this therapeutic modality.https://www.mdpi.com/2076-3417/12/23/12276photodynamic therapyphotosensitizersveterinary oncology |
| spellingShingle | Tarcísio Guerra Guimarães Karla Menezes Cardoso Carlos Miguel Marto Ricardo Teixo Beatriz Serambeque Fernando Capela e Silva Nuno Alexandre Maria Filomena Botelho Mafalda Laranjo Oncological Applications of Photodynamic Therapy in Dogs and Cats Applied Sciences photodynamic therapy photosensitizers veterinary oncology |
| title | Oncological Applications of Photodynamic Therapy in Dogs and Cats |
| title_full | Oncological Applications of Photodynamic Therapy in Dogs and Cats |
| title_fullStr | Oncological Applications of Photodynamic Therapy in Dogs and Cats |
| title_full_unstemmed | Oncological Applications of Photodynamic Therapy in Dogs and Cats |
| title_short | Oncological Applications of Photodynamic Therapy in Dogs and Cats |
| title_sort | oncological applications of photodynamic therapy in dogs and cats |
| topic | photodynamic therapy photosensitizers veterinary oncology |
| url | https://www.mdpi.com/2076-3417/12/23/12276 |
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