Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics
An efficient solid-phase-supported peptide synthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as fir...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2014-05-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.10.115 |
| _version_ | 1830192023945084928 |
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| author | Tatyana V. Abramova Sergey S. Belov Yulia V. Tarasenko Vladimir N. Silnikov |
| author_facet | Tatyana V. Abramova Sergey S. Belov Yulia V. Tarasenko Vladimir N. Silnikov |
| author_sort | Tatyana V. Abramova |
| collection | DOAJ |
| description | An efficient solid-phase-supported peptide synthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as first subunits. |
| first_indexed | 2024-12-17T23:48:56Z |
| format | Article |
| id | doaj.art-544ecf79d02249668ef3f02d0d17de4f |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-17T23:48:56Z |
| publishDate | 2014-05-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-544ecf79d02249668ef3f02d0d17de4f2022-12-21T21:28:14ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-05-011011151115810.3762/bjoc.10.1151860-5397-10-115Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimicsTatyana V. Abramova0Sergey S. Belov1Yulia V. Tarasenko2Vladimir N. Silnikov3Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent’ev Ave, 8, Novosibirsk 630090, RussiaInstitute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent’ev Ave, 8, Novosibirsk 630090, RussiaInstitute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent’ev Ave, 8, Novosibirsk 630090, RussiaInstitute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent’ev Ave, 8, Novosibirsk 630090, RussiaAn efficient solid-phase-supported peptide synthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as first subunits.https://doi.org/10.3762/bjoc.10.115labile linkermorpholino oligomersoligonucleotide mimicssolid-phase-supported peptide synthesis (SPPS) |
| spellingShingle | Tatyana V. Abramova Sergey S. Belov Yulia V. Tarasenko Vladimir N. Silnikov Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics Beilstein Journal of Organic Chemistry labile linker morpholino oligomers oligonucleotide mimics solid-phase-supported peptide synthesis (SPPS) |
| title | Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics |
| title_full | Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics |
| title_fullStr | Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics |
| title_full_unstemmed | Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics |
| title_short | Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics |
| title_sort | solid phase supported synthesis of morpholinoglycine oligonucleotide mimics |
| topic | labile linker morpholino oligomers oligonucleotide mimics solid-phase-supported peptide synthesis (SPPS) |
| url | https://doi.org/10.3762/bjoc.10.115 |
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