Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer’s disease
Recent studies have shown that increased cognitive intraindividual variability (IIV) across accuracy scores from tests representing different cognitive domains (across-domain IIV) might indicate prodromal Alzheimer’s disease (AD). Although IIV has been proposed to index cognitive control processes,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-07-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00147/full |
| _version_ | 1817971322600292352 |
|---|---|
| author | Andrea Maria Kälin Marlon ePflüger Anton Franz Gietl Florian eRiese Lutz eJäncke Lutz eJäncke Lutz eJäncke Roger M. Nitsch Christoph eHock |
| author_facet | Andrea Maria Kälin Marlon ePflüger Anton Franz Gietl Florian eRiese Lutz eJäncke Lutz eJäncke Lutz eJäncke Roger M. Nitsch Christoph eHock |
| author_sort | Andrea Maria Kälin |
| collection | DOAJ |
| description | Recent studies have shown that increased cognitive intraindividual variability (IIV) across accuracy scores from tests representing different cognitive domains (across-domain IIV) might indicate prodromal Alzheimer’s disease (AD). Although IIV has been proposed to index cognitive control processes, IIV across accuracy scores from cognitive control tasks (within-domain IIV) has not been examined in healthy controls subjects (HCS), mild cognitive impairment (MCI) and AD patients in a single comparative study. This study examines the discriminative properties of within-domain IIV, and across-domain IIV in 149 HCS, 31 MCI and 26 AD. Three tasks representing different cognitive domains were identified to calculate across-domain IIV. Three other tasks representing cognitive control were identified to calculate within-domain IIV. The intraindividual standard deviation (ISD) was calculated across accuracy scores. To compare IIV between groups, ANCOVAs with the covariates age, gender, education, and mean performance were computed. IIV scores in general were higher in AD vs. HCS (p< 0.01). Only across-domain IIV was higher in AD vs. MCI (p=0.001), and only within-domain IIV was higher in MCI vs. HCS (p=0.05). Within-domain IIV may constitute a cognitive marker for the detection of prodromal AD at the MCI stage, whereas across-domain IIV may detect beginning AD at the MCI stage. |
| first_indexed | 2024-04-13T20:45:20Z |
| format | Article |
| id | doaj.art-544f351d5c17443898c80a59b4443cfc |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T20:45:20Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-544f351d5c17443898c80a59b4443cfc2022-12-22T02:30:42ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652014-07-01610.3389/fnagi.2014.0014789204Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer’s diseaseAndrea Maria Kälin0Marlon ePflüger1Anton Franz Gietl2Florian eRiese3Lutz eJäncke4Lutz eJäncke5Lutz eJäncke6Roger M. Nitsch7Christoph eHock8Division of Psychiatry Research and Psychogeriatric Medicine, University of ZurichDepartment of Forensic Psychiatry, Psychiatric University Clinics, University of BaselDivision of Psychiatry Research and Psychogeriatric Medicine, University of ZurichDivision of Psychiatry Research and Psychogeriatric Medicine, University of ZurichDivision Neuropsychology, Institute of Psychology, University of ZurichInternational Normal Aging and Plasticity Imaging Center (INAPIC), University of ZurichUniversity Research Priority Program (URPP) Dynamics of healthy aging, University of ZurichDivision of Psychiatry Research and Psychogeriatric Medicine, University of ZurichDivision of Psychiatry Research and Psychogeriatric Medicine, University of ZurichRecent studies have shown that increased cognitive intraindividual variability (IIV) across accuracy scores from tests representing different cognitive domains (across-domain IIV) might indicate prodromal Alzheimer’s disease (AD). Although IIV has been proposed to index cognitive control processes, IIV across accuracy scores from cognitive control tasks (within-domain IIV) has not been examined in healthy controls subjects (HCS), mild cognitive impairment (MCI) and AD patients in a single comparative study. This study examines the discriminative properties of within-domain IIV, and across-domain IIV in 149 HCS, 31 MCI and 26 AD. Three tasks representing different cognitive domains were identified to calculate across-domain IIV. Three other tasks representing cognitive control were identified to calculate within-domain IIV. The intraindividual standard deviation (ISD) was calculated across accuracy scores. To compare IIV between groups, ANCOVAs with the covariates age, gender, education, and mean performance were computed. IIV scores in general were higher in AD vs. HCS (p< 0.01). Only across-domain IIV was higher in AD vs. MCI (p=0.001), and only within-domain IIV was higher in MCI vs. HCS (p=0.05). Within-domain IIV may constitute a cognitive marker for the detection of prodromal AD at the MCI stage, whereas across-domain IIV may detect beginning AD at the MCI stage.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00147/fullMild Cognitive ImpairmentNeuropsychologycognitive controlAlzheimer’s diseaseearly diagnosiscognitive variability |
| spellingShingle | Andrea Maria Kälin Marlon ePflüger Anton Franz Gietl Florian eRiese Lutz eJäncke Lutz eJäncke Lutz eJäncke Roger M. Nitsch Christoph eHock Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer’s disease Frontiers in Aging Neuroscience Mild Cognitive Impairment Neuropsychology cognitive control Alzheimer’s disease early diagnosis cognitive variability |
| title | Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer’s disease |
| title_full | Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer’s disease |
| title_fullStr | Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer’s disease |
| title_full_unstemmed | Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer’s disease |
| title_short | Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer’s disease |
| title_sort | intraindividual variability across cognitive tasks as a potential marker for prodromal alzheimer s disease |
| topic | Mild Cognitive Impairment Neuropsychology cognitive control Alzheimer’s disease early diagnosis cognitive variability |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00147/full |
| work_keys_str_mv | AT andreamariakalin intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease AT marlonepfluger intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease AT antonfranzgietl intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease AT florianeriese intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease AT lutzejancke intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease AT lutzejancke intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease AT lutzejancke intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease AT rogermnitsch intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease AT christophehock intraindividualvariabilityacrosscognitivetasksasapotentialmarkerforprodromalalzheimersdisease |