Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC
Abstract Background Exosome-mediated interaction serves as a significant regulatory factor for M2 macrophage polarization in cancer. Methods All accessible data were acquired from The Cancer Genome Atlas (TCGA) database and analyzed using R software. Molecules implicated in exocrine secretion were a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2023-09-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-023-00797-x |
| _version_ | 1797558798067433472 |
|---|---|
| author | Yang Xue Zhengyan Cheng Yida Liao Xing Chen |
| author_facet | Yang Xue Zhengyan Cheng Yida Liao Xing Chen |
| author_sort | Yang Xue |
| collection | DOAJ |
| description | Abstract Background Exosome-mediated interaction serves as a significant regulatory factor for M2 macrophage polarization in cancer. Methods All accessible data were acquired from The Cancer Genome Atlas (TCGA) database and analyzed using R software. Molecules implicated in exocrine secretion were amassed from the ExoCarta database. Our research initially quantified the immune microenvironment in Esophageal Squamous Cell Carcinoma (ESCC) patients based on the expression profile sourced from the TCGA database. Additionally, we delved into the biological role of M2 macrophages in ESCC via Gene Set Enrichment Analysis (GSEA). Results We observed that patients with high M2 macrophage infiltration typically have a poorer prognosis. Subsequently, a total of 1457 molecules were identified, with 103 of these molecules believed to function through exocrine mechanisms, as supported by data from the ExoCarta database. SNORD91A and SLC40A1 were ultimately pinpointed due to their correlation with patient prognosis. Moreover, we investigated their potential roles in ESCC, including biological enrichment, immune infiltration, and genomic instability analysis. Conclusions Our study identified exosome-associated molecules, namely SNORD91A and SLC40A1, which notably impact ESCC prognosis and local M2 macrophage recruitment, thereby presenting potential therapeutic targets for ESCC. |
| first_indexed | 2024-03-10T17:36:28Z |
| format | Article |
| id | doaj.art-544f90283b0b4937987bc4a9c2366d30 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-03-10T17:36:28Z |
| publishDate | 2023-09-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-544f90283b0b4937987bc4a9c2366d302023-11-20T09:50:27ZengSpringerDiscover Oncology2730-60112023-09-0114111110.1007/s12672-023-00797-xRole of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCCYang Xue0Zhengyan Cheng1Yida Liao2Xing Chen3Department of Thoracic Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s HospitalDepartment of Pathology, Sichuan Academy of Medical Science & Sichuan Provincial People’s HospitalDepartment of Thoracic Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s HospitalDepartment of Thoracic Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s HospitalAbstract Background Exosome-mediated interaction serves as a significant regulatory factor for M2 macrophage polarization in cancer. Methods All accessible data were acquired from The Cancer Genome Atlas (TCGA) database and analyzed using R software. Molecules implicated in exocrine secretion were amassed from the ExoCarta database. Our research initially quantified the immune microenvironment in Esophageal Squamous Cell Carcinoma (ESCC) patients based on the expression profile sourced from the TCGA database. Additionally, we delved into the biological role of M2 macrophages in ESCC via Gene Set Enrichment Analysis (GSEA). Results We observed that patients with high M2 macrophage infiltration typically have a poorer prognosis. Subsequently, a total of 1457 molecules were identified, with 103 of these molecules believed to function through exocrine mechanisms, as supported by data from the ExoCarta database. SNORD91A and SLC40A1 were ultimately pinpointed due to their correlation with patient prognosis. Moreover, we investigated their potential roles in ESCC, including biological enrichment, immune infiltration, and genomic instability analysis. Conclusions Our study identified exosome-associated molecules, namely SNORD91A and SLC40A1, which notably impact ESCC prognosis and local M2 macrophage recruitment, thereby presenting potential therapeutic targets for ESCC.https://doi.org/10.1007/s12672-023-00797-xESCCExosomesM2 Macrophage PolarizationSNORD91ASLC40A1 |
| spellingShingle | Yang Xue Zhengyan Cheng Yida Liao Xing Chen Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC Discover Oncology ESCC Exosomes M2 Macrophage Polarization SNORD91A SLC40A1 |
| title | Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC |
| title_full | Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC |
| title_fullStr | Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC |
| title_full_unstemmed | Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC |
| title_short | Role of exosome-mediated molecules SNORD91A and SLC40A1 in M2 macrophage polarization and prognosis of ESCC |
| title_sort | role of exosome mediated molecules snord91a and slc40a1 in m2 macrophage polarization and prognosis of escc |
| topic | ESCC Exosomes M2 Macrophage Polarization SNORD91A SLC40A1 |
| url | https://doi.org/10.1007/s12672-023-00797-x |
| work_keys_str_mv | AT yangxue roleofexosomemediatedmoleculessnord91aandslc40a1inm2macrophagepolarizationandprognosisofescc AT zhengyancheng roleofexosomemediatedmoleculessnord91aandslc40a1inm2macrophagepolarizationandprognosisofescc AT yidaliao roleofexosomemediatedmoleculessnord91aandslc40a1inm2macrophagepolarizationandprognosisofescc AT xingchen roleofexosomemediatedmoleculessnord91aandslc40a1inm2macrophagepolarizationandprognosisofescc |