Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

<p>Abstract</p> <p>Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejectio...

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Bibliographic Details
Main Authors: Gutberlet Matthias, Lurz Philipp, Fuernau Georg, de Waha Suzanne, Eitel Ingo, Desch Steffen, Schuler Gerhard, Thiele Holger
Format: Article
Language:English
Published: BMC 2011-09-01
Series:Trials
Subjects:
Online Access:http://www.trialsjournal.com/content/12/1/204
Description
Summary:<p>Abstract</p> <p>Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented.</p>
ISSN:1745-6215