NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy
The graphene-based materials have been used as a potential coating material for nanoparticles due to their excellent passivation. Herein, we report for the first time the colloidal stability, photothermal profile, thermal stability, cytotoxicity, and photo-cytotoxicity of graphene quantum dots (GQDs...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-06-01
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| Series: | Nanotechnology Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/ntrev-2022-0541 |
| _version_ | 1797806230526230528 |
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| author | Lebepe Thabang C. Parani Sundararajan Maluleke Rodney Ncapayi Vuyelwa Aladesuyi Olanrewaju A. Komiya Atsuki Kodama Tetsuya Oluwafemi Oluwatobi S. |
| author_facet | Lebepe Thabang C. Parani Sundararajan Maluleke Rodney Ncapayi Vuyelwa Aladesuyi Olanrewaju A. Komiya Atsuki Kodama Tetsuya Oluwafemi Oluwatobi S. |
| author_sort | Lebepe Thabang C. |
| collection | DOAJ |
| description | The graphene-based materials have been used as a potential coating material for nanoparticles due to their excellent passivation. Herein, we report for the first time the colloidal stability, photothermal profile, thermal stability, cytotoxicity, and photo-cytotoxicity of graphene quantum dots (GQDs) coupled with the second infrared window (NIR-II) absorbing gold nanorods (AuNRs/GQDs) and compare it to graphene oxide (GO)-coated NIR-II absorbing AuNRs (AuNRs/GO). The composites were achieved by electrostatic interaction of the GO or GQDs with AuNRs. The results revealed that (i) AuNRs/GQDs were more stable in the aqueous phosphate buffer and cell culture media than AuNRs/GO and AuNRs; (ii) GO enhanced the photothermal efficiency of the AuNRs, whereas GQDs reduced it; (iii) GQDs enhanced the photothermal stability of AuNRs than GO; (iv) both AuNRs/GO and AuNRs/GQDs were biocompatible with mouse colon carcinoma (C26) cell lines and malignant fibrous histiocytoma‐like, expressing a fusion of the luciferase and enhanced green fluorescent protein genes (KM-Luc/GFP) cell lines; and (v) photo-cytotoxicity of AuNRs/GO and AuNRs/GQDs conducted against C26 cell lines showed significantly improved cell death compared to laser irradiation alone; however, AuNRs/GO exhibited high photo-toxicity than AuNRs/GQDs. This study shows that AuNRs/GO and AuNRs/GQDs composites possess unique properties to improve AuNRs and be utilised in photothermal applications. |
| first_indexed | 2024-03-13T06:04:08Z |
| format | Article |
| id | doaj.art-545164dc9cb347559cc5806d068b83ac |
| institution | Directory Open Access Journal |
| issn | 2191-9097 |
| language | English |
| last_indexed | 2024-03-13T06:04:08Z |
| publishDate | 2023-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanotechnology Reviews |
| spelling | doaj.art-545164dc9cb347559cc5806d068b83ac2023-06-12T06:31:29ZengDe GruyterNanotechnology Reviews2191-90972023-06-01121189190710.1515/ntrev-2022-0541NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapyLebepe Thabang C.0Parani Sundararajan1Maluleke Rodney2Ncapayi Vuyelwa3Aladesuyi Olanrewaju A.4Komiya Atsuki5Kodama Tetsuya6Oluwafemi Oluwatobi S.7Department of Chemical Science, University of Johannesburg, Johannesburg, 2028, South AfricaDepartment of Chemical Science, University of Johannesburg, Johannesburg, 2028, South AfricaDepartment of Chemical Science, University of Johannesburg, Johannesburg, 2028, South AfricaDepartment of Chemical Science, University of Johannesburg, Johannesburg, 2028, South AfricaDepartment of Chemical Science, University of Johannesburg, Johannesburg, 2028, South AfricaGraduate School of Engineering, Institute of Fluid Science, Tohoku University, Sendai, 980-8577, JapanLaboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, Sendai, 980-8575, JapanDepartment of Chemical Science, University of Johannesburg, Johannesburg, 2028, South AfricaThe graphene-based materials have been used as a potential coating material for nanoparticles due to their excellent passivation. Herein, we report for the first time the colloidal stability, photothermal profile, thermal stability, cytotoxicity, and photo-cytotoxicity of graphene quantum dots (GQDs) coupled with the second infrared window (NIR-II) absorbing gold nanorods (AuNRs/GQDs) and compare it to graphene oxide (GO)-coated NIR-II absorbing AuNRs (AuNRs/GO). The composites were achieved by electrostatic interaction of the GO or GQDs with AuNRs. The results revealed that (i) AuNRs/GQDs were more stable in the aqueous phosphate buffer and cell culture media than AuNRs/GO and AuNRs; (ii) GO enhanced the photothermal efficiency of the AuNRs, whereas GQDs reduced it; (iii) GQDs enhanced the photothermal stability of AuNRs than GO; (iv) both AuNRs/GO and AuNRs/GQDs were biocompatible with mouse colon carcinoma (C26) cell lines and malignant fibrous histiocytoma‐like, expressing a fusion of the luciferase and enhanced green fluorescent protein genes (KM-Luc/GFP) cell lines; and (v) photo-cytotoxicity of AuNRs/GO and AuNRs/GQDs conducted against C26 cell lines showed significantly improved cell death compared to laser irradiation alone; however, AuNRs/GO exhibited high photo-toxicity than AuNRs/GQDs. This study shows that AuNRs/GO and AuNRs/GQDs composites possess unique properties to improve AuNRs and be utilised in photothermal applications.https://doi.org/10.1515/ntrev-2022-0541gold nanorodsgraphene oxidegraphene quantum dotsstabilitycytotoxicityphotothermal therapy |
| spellingShingle | Lebepe Thabang C. Parani Sundararajan Maluleke Rodney Ncapayi Vuyelwa Aladesuyi Olanrewaju A. Komiya Atsuki Kodama Tetsuya Oluwafemi Oluwatobi S. NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy Nanotechnology Reviews gold nanorods graphene oxide graphene quantum dots stability cytotoxicity photothermal therapy |
| title | NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy |
| title_full | NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy |
| title_fullStr | NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy |
| title_full_unstemmed | NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy |
| title_short | NIR-II window absorbing graphene oxide-coated gold nanorods and graphene quantum dot-coupled gold nanorods for photothermal cancer therapy |
| title_sort | nir ii window absorbing graphene oxide coated gold nanorods and graphene quantum dot coupled gold nanorods for photothermal cancer therapy |
| topic | gold nanorods graphene oxide graphene quantum dots stability cytotoxicity photothermal therapy |
| url | https://doi.org/10.1515/ntrev-2022-0541 |
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