Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats
Introduction: Broad neural circuits originate from the hypothalamic arcuate nucleus and project to many parts of the brain which are related to pain perception. Insulin receptors are found in the arcuate nucleus. Since nociception may be affected in type 1 diabetes, the present study aimed to invest...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2020-11-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/article-1-1583-en.html |
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| author | Hossein Khaleghzadeh-Ahangar Forouzan Sadeghimahalli Shaghayegh Khandan Sima Shahabi Aliakbar Moghadamnia |
| author_facet | Hossein Khaleghzadeh-Ahangar Forouzan Sadeghimahalli Shaghayegh Khandan Sima Shahabi Aliakbar Moghadamnia |
| author_sort | Hossein Khaleghzadeh-Ahangar |
| collection | DOAJ |
| description | Introduction: Broad neural circuits originate from the hypothalamic arcuate nucleus and project to many parts of the brain which are related to pain perception. Insulin receptors are found in the arcuate nucleus. Since nociception may be affected in type 1 diabetes, the present study aimed to investigate the intra-arcuate nucleus insulin role in pain perception in streptozotocin (STZ)-induced diabetic and healthy rats.
Methods: Regular insulin was microinjected within the arcuate nucleus and the pain tolerance was measured using the hot plate and the tail-flick apparatus in diabetic rats.
Results: The results showed that the arcuate nucleus suppression with lidocaine could increase thermal nociception in non-diabetic animals. Also, insulin within the arcuate nucleus decreased the acute thermal pain perception in these animals. STZ-induced diabetes produced hypoalgesia which the latency of these tests, progressively increased over time after induction of diabetes. Also, in the same animal group, intra-arcuate injection of insulin reduced the latency of nociception.
Conclusion: Intra-arcuate insulin has paradoxical and controversial effects in healthy and diabetic rats’ nociception. These effects seem to be due to the insulin effect on releasing pro-opiomelanocortin and its deriv |
| first_indexed | 2024-03-07T16:55:53Z |
| format | Article |
| id | doaj.art-54517187b4de4ea49b8d3c632aa243ab |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:55:53Z |
| publishDate | 2020-11-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-54517187b4de4ea49b8d3c632aa243ab2024-03-03T04:22:14ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422020-11-01116727736Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic RatsHossein Khaleghzadeh-Ahangar0Forouzan Sadeghimahalli1Shaghayegh Khandan2Sima Shahabi3Aliakbar Moghadamnia4 Department of Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Departement of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Introduction: Broad neural circuits originate from the hypothalamic arcuate nucleus and project to many parts of the brain which are related to pain perception. Insulin receptors are found in the arcuate nucleus. Since nociception may be affected in type 1 diabetes, the present study aimed to investigate the intra-arcuate nucleus insulin role in pain perception in streptozotocin (STZ)-induced diabetic and healthy rats. Methods: Regular insulin was microinjected within the arcuate nucleus and the pain tolerance was measured using the hot plate and the tail-flick apparatus in diabetic rats. Results: The results showed that the arcuate nucleus suppression with lidocaine could increase thermal nociception in non-diabetic animals. Also, insulin within the arcuate nucleus decreased the acute thermal pain perception in these animals. STZ-induced diabetes produced hypoalgesia which the latency of these tests, progressively increased over time after induction of diabetes. Also, in the same animal group, intra-arcuate injection of insulin reduced the latency of nociception. Conclusion: Intra-arcuate insulin has paradoxical and controversial effects in healthy and diabetic rats’ nociception. These effects seem to be due to the insulin effect on releasing pro-opiomelanocortin and its derivhttp://bcn.iums.ac.ir/article-1-1583-en.htmlthe arcuate nucleusinsulinhot platetail-flickacute pain |
| spellingShingle | Hossein Khaleghzadeh-Ahangar Forouzan Sadeghimahalli Shaghayegh Khandan Sima Shahabi Aliakbar Moghadamnia Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats Basic and Clinical Neuroscience the arcuate nucleus insulin hot plate tail-flick acute pain |
| title | Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats |
| title_full | Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats |
| title_fullStr | Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats |
| title_full_unstemmed | Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats |
| title_short | Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats |
| title_sort | insulin within the arcuate nucleus has paradoxical effects on nociception in healthy and diabetic rats |
| topic | the arcuate nucleus insulin hot plate tail-flick acute pain |
| url | http://bcn.iums.ac.ir/article-1-1583-en.html |
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