Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention
Oropharyngeal mucositis is the acute inflammatory and ulcerative reaction of the oral mucosa following radiation therapy to the head and neck region. It is such a common problem that nearly all head and neck cancer patients develop some degree of mucositis. This complication is usually transient in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-12-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/116 |
| _version_ | 1797963078315278336 |
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| author | Wei Cheong Ngeow Wen Lin Chai Rosnah Binti Zain |
| author_facet | Wei Cheong Ngeow Wen Lin Chai Rosnah Binti Zain |
| author_sort | Wei Cheong Ngeow |
| collection | DOAJ |
| description | Oropharyngeal mucositis is the acute inflammatory and ulcerative reaction of the oral mucosa following radiation therapy to the head and neck region. It is such a common problem that nearly all head and neck cancer patients develop some degree of mucositis. This complication is usually transient in nature but it also represents an important clinical problem as it is a painful, debilitating, dose-dependent side effect for which there is no widely acceptable prophylaxis or effective treatment. As several authoritative groups have recently either undertaken systematic reviews or issued guidelines on the management of mucositis, it is the aim of this review to provide instead an overview of all the possible remedies available, as well as highlighting to researchers the gaps that need to be filled. The first part of this review outlines the clinical significance and pathophysiology of radiation-induced mucositis, and looks into some of the preventive approaches available. |
| first_indexed | 2024-04-11T01:22:42Z |
| format | Article |
| id | doaj.art-5452dafc3fdc4b508741d10254b07a61 |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:22:42Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-5452dafc3fdc4b508741d10254b07a612023-01-03T11:00:15ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652011-12-012210.4081/oncol.2008.102110Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and preventionWei Cheong Ngeow0Wen Lin Chai1Rosnah Binti Zain2Department of Oral & Maxillofacial Surgery Faculty of Dentistry, University of Malaya, Kuala LumpurDepartment of General Dental Practice and Oral & Maxillofacial Imaging, Faculty of Dentistry, University of Malaya, Kuala LumpurDepartment of Oral Pathology, Oral Medicine and Periodontology Faculty of Dentistry,University of Malaya, Kuala LumpurOropharyngeal mucositis is the acute inflammatory and ulcerative reaction of the oral mucosa following radiation therapy to the head and neck region. It is such a common problem that nearly all head and neck cancer patients develop some degree of mucositis. This complication is usually transient in nature but it also represents an important clinical problem as it is a painful, debilitating, dose-dependent side effect for which there is no widely acceptable prophylaxis or effective treatment. As several authoritative groups have recently either undertaken systematic reviews or issued guidelines on the management of mucositis, it is the aim of this review to provide instead an overview of all the possible remedies available, as well as highlighting to researchers the gaps that need to be filled. The first part of this review outlines the clinical significance and pathophysiology of radiation-induced mucositis, and looks into some of the preventive approaches available.http://www.oncologyreviews.org/index.php/or/article/view/116Head and neck cancer - Radiation therapy - Mucositis - Management |
| spellingShingle | Wei Cheong Ngeow Wen Lin Chai Rosnah Binti Zain Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention Oncology Reviews Head and neck cancer - Radiation therapy - Mucositis - Management |
| title | Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention |
| title_full | Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention |
| title_fullStr | Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention |
| title_full_unstemmed | Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention |
| title_short | Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention |
| title_sort | management of radiation therapy induced mucositis in head and neck cancer patients part i clinical significance pathophysiology and prevention |
| topic | Head and neck cancer - Radiation therapy - Mucositis - Management |
| url | http://www.oncologyreviews.org/index.php/or/article/view/116 |
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