High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated module
Abstract Spleen stiffness measurement (SSM) by vibration‐controlled transient elastography (VCTE) is a noninvasive technique for estimating portal hypertension in patients with chronic liver disease (CLD), with its reproducibility yet to be established and its feasibility still unknown beyond CLD. W...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2022-11-01
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| Series: | Hepatology Communications |
| Online Access: | https://doi.org/10.1002/hep4.2070 |
| _version_ | 1797760553387556864 |
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| author | Cristina Rigamonti Micol Giulia Cittone Giulia Francesca Manfredi Andrea Sorge Riccardo Moia Andrea Patriarca Maria Francesca Donato Gianluca Gaidano Mario Pirisi Mirella Fraquelli |
| author_facet | Cristina Rigamonti Micol Giulia Cittone Giulia Francesca Manfredi Andrea Sorge Riccardo Moia Andrea Patriarca Maria Francesca Donato Gianluca Gaidano Mario Pirisi Mirella Fraquelli |
| author_sort | Cristina Rigamonti |
| collection | DOAJ |
| description | Abstract Spleen stiffness measurement (SSM) by vibration‐controlled transient elastography (VCTE) is a noninvasive technique for estimating portal hypertension in patients with chronic liver disease (CLD), with its reproducibility yet to be established and its feasibility still unknown beyond CLD. We have studied 420 participants from two tertiary referral centers for liver diseases (Novara, Milan): 297 patients with CLD (32% with cirrhosis) of different etiology (Group A), 63 Philadelphia‐negative myeloproliferative neoplasms (Group B), and 60 heathy volunteers (Group C). All underwent SSM by VCTE with a spleen‐dedicated module (SSM@100 Hz) and liver stiffness measurement (LSM), blindly performed by 2 different operators. In total, 1680 VCTE examinations for SSM were performed (1000 in Novara, 680 in Milan), with an overall 3.2% failure rate. Median SSM was 26.5 kPa (interquartile range [IQR] 20.0–42.3) in Group A, 26.3 kPa (IQR 22.3–33.6) in Group B, and 16.1 kPa (IQR 14.6–18.7) in Group C. In Group A, the median LSM was 6.8 kPa (IQR 4.9–11.3) in Novara and 8.3 kPa (IQR 7.1–10.8) in Milan, the proportion of patients with cirrhosis being 34% in Novara and 31% in Milan. The Group A interobserver agreement ICC was 0.90 (0.88–0.92), significantly lower in the absence of splenomegaly (ICC 0.87 vs. 0.91) and in absence of cirrhosis (ICC 0.84 vs. 0.90); overweight slightly, but not significantly reduced the interobserveragreement. The intra‐observer agreement ICC ranged from 0.91 to 0.96 for the four operators. The Group B interobserver agreement ICC was 0.90 (0.83–0.94). In conclusion, SSM measured by the new spleen‐dedicated VCTE module is a feasible, reliable, and highly reproducible tool in patients with CLD and hematological disorders, and in healthy volunteers. |
| first_indexed | 2024-03-12T19:00:15Z |
| format | Article |
| id | doaj.art-545367aa94f2492293c815b5ba0bac54 |
| institution | Directory Open Access Journal |
| issn | 2471-254X |
| language | English |
| last_indexed | 2024-03-12T19:00:15Z |
| publishDate | 2022-11-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj.art-545367aa94f2492293c815b5ba0bac542023-08-02T06:40:17ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2022-11-016113006301410.1002/hep4.2070High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated moduleCristina Rigamonti0Micol Giulia Cittone1Giulia Francesca Manfredi2Andrea Sorge3Riccardo Moia4Andrea Patriarca5Maria Francesca Donato6Gianluca Gaidano7Mario Pirisi8Mirella Fraquelli9Department of Translational Medicine Università del Piemonte Orientale and Division of Internal Medicine, Azienda Ospedaliero‐Universitaria Maggiore della Carità Novara ItalyDepartment of Translational Medicine Università del Piemonte Orientale and Division of Internal Medicine, Azienda Ospedaliero‐Universitaria Maggiore della Carità Novara ItalyDepartment of Translational Medicine Università del Piemonte Orientale and Division of Internal Medicine, Azienda Ospedaliero‐Universitaria Maggiore della Carità Novara ItalyGastroenterology and Endoscopy Unit Fondazione IRCCS Ca' Granda–Ospedale Maggiore Policlinico Milan ItalyDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and Azienda Ospedaliero–Universitaria Maggiore della Carità Novara ItalyDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and Azienda Ospedaliero–Universitaria Maggiore della Carità Novara ItalyGastroenterology and Hepatology Unit Fondazione IRCCS Ca' Granda–Ospedale Maggiore Policlinico Milan ItalyDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and Azienda Ospedaliero–Universitaria Maggiore della Carità Novara ItalyDepartment of Translational Medicine Università del Piemonte Orientale and Division of Internal Medicine, Azienda Ospedaliero‐Universitaria Maggiore della Carità Novara ItalyGastroenterology and Endoscopy Unit Fondazione IRCCS Ca' Granda–Ospedale Maggiore Policlinico Milan ItalyAbstract Spleen stiffness measurement (SSM) by vibration‐controlled transient elastography (VCTE) is a noninvasive technique for estimating portal hypertension in patients with chronic liver disease (CLD), with its reproducibility yet to be established and its feasibility still unknown beyond CLD. We have studied 420 participants from two tertiary referral centers for liver diseases (Novara, Milan): 297 patients with CLD (32% with cirrhosis) of different etiology (Group A), 63 Philadelphia‐negative myeloproliferative neoplasms (Group B), and 60 heathy volunteers (Group C). All underwent SSM by VCTE with a spleen‐dedicated module (SSM@100 Hz) and liver stiffness measurement (LSM), blindly performed by 2 different operators. In total, 1680 VCTE examinations for SSM were performed (1000 in Novara, 680 in Milan), with an overall 3.2% failure rate. Median SSM was 26.5 kPa (interquartile range [IQR] 20.0–42.3) in Group A, 26.3 kPa (IQR 22.3–33.6) in Group B, and 16.1 kPa (IQR 14.6–18.7) in Group C. In Group A, the median LSM was 6.8 kPa (IQR 4.9–11.3) in Novara and 8.3 kPa (IQR 7.1–10.8) in Milan, the proportion of patients with cirrhosis being 34% in Novara and 31% in Milan. The Group A interobserver agreement ICC was 0.90 (0.88–0.92), significantly lower in the absence of splenomegaly (ICC 0.87 vs. 0.91) and in absence of cirrhosis (ICC 0.84 vs. 0.90); overweight slightly, but not significantly reduced the interobserveragreement. The intra‐observer agreement ICC ranged from 0.91 to 0.96 for the four operators. The Group B interobserver agreement ICC was 0.90 (0.83–0.94). In conclusion, SSM measured by the new spleen‐dedicated VCTE module is a feasible, reliable, and highly reproducible tool in patients with CLD and hematological disorders, and in healthy volunteers.https://doi.org/10.1002/hep4.2070 |
| spellingShingle | Cristina Rigamonti Micol Giulia Cittone Giulia Francesca Manfredi Andrea Sorge Riccardo Moia Andrea Patriarca Maria Francesca Donato Gianluca Gaidano Mario Pirisi Mirella Fraquelli High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated module Hepatology Communications |
| title | High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated module |
| title_full | High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated module |
| title_fullStr | High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated module |
| title_full_unstemmed | High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated module |
| title_short | High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated module |
| title_sort | high reproducibility of spleen stiffness measurement by vibration controlled transient elastography with a spleen dedicated module |
| url | https://doi.org/10.1002/hep4.2070 |
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