The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma—A Nation-Wide Swedish Population-Based Retrospective Register Study
Previous studies have demonstrated an anti-tumoral effect of beta-adrenergic blocking agents on cutaneous melanoma (CM). The aim of this study was to investigate if beta-adrenergic blocking agents have an impact on survival in Swedish patients with melanoma. A population-based retrospective registry...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/11/3228 |
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| author | Dimitrios Katsarelias Hanna Eriksson Rasmus Mikiver Isabelle Krakowski Jonas A. Nilsson Lars Ny Roger Olofsson Bagge |
| author_facet | Dimitrios Katsarelias Hanna Eriksson Rasmus Mikiver Isabelle Krakowski Jonas A. Nilsson Lars Ny Roger Olofsson Bagge |
| author_sort | Dimitrios Katsarelias |
| collection | DOAJ |
| description | Previous studies have demonstrated an anti-tumoral effect of beta-adrenergic blocking agents on cutaneous melanoma (CM). The aim of this study was to investigate if beta-adrenergic blocking agents have an impact on survival in Swedish patients with melanoma. A population-based retrospective registry study including all patients diagnosed with a primary invasive melanoma between 2009 and 2013 was performed. Data from the Swedish Melanoma Register were linked to the Swedish Prescribed Drug Registry and the Swedish Cause of Death Register. Cox regression analyses including competing risk assessments were performed. There were 12,738 patients included, out of which 3702 were exposed to beta-blockers vs. 9036 non-exposed patients. Age, male sex, Breslow thickness, ulceration, and nodal status were independent negative prognostic factors for melanoma-specific survival (MSS). Adding beta-blockers to the analysis did not add any prognostic value to the model (HR 1.00, <i>p</i> = 0.98), neither when adjusting for competing risks (HR 0.97, <i>p</i> = 0.61). When specifically analyzing the use of non-selective beta-blockers, the results were still without statistical significance (HR 0.76, <i>p</i> = 0.21). In conclusion, this population-based registry study could not verify that the use of beta-adrenergic blocking agents improve survival in patients with melanoma. |
| first_indexed | 2024-03-10T15:08:58Z |
| format | Article |
| id | doaj.art-545597b5db8943698799f84b2336b9b1 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:08:58Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-545597b5db8943698799f84b2336b9b12023-11-20T19:30:19ZengMDPI AGCancers2072-66942020-11-011211322810.3390/cancers12113228The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma—A Nation-Wide Swedish Population-Based Retrospective Register StudyDimitrios Katsarelias0Hanna Eriksson1Rasmus Mikiver2Isabelle Krakowski3Jonas A. Nilsson4Lars Ny5Roger Olofsson Bagge6Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Oncology and Pathology, Karolinska Institutet, 171 64 Stockholm, SwedenRegional Cancer Center South East Sweden and Department of Clinical and Experimental Medicine, Linköping University, 581 83 Linköping, SwedenDepartment of Oncology and Pathology, Karolinska Institutet, 171 64 Stockholm, SwedenDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Oncology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, 405 30 Gothenburg, SwedenDepartment of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenPrevious studies have demonstrated an anti-tumoral effect of beta-adrenergic blocking agents on cutaneous melanoma (CM). The aim of this study was to investigate if beta-adrenergic blocking agents have an impact on survival in Swedish patients with melanoma. A population-based retrospective registry study including all patients diagnosed with a primary invasive melanoma between 2009 and 2013 was performed. Data from the Swedish Melanoma Register were linked to the Swedish Prescribed Drug Registry and the Swedish Cause of Death Register. Cox regression analyses including competing risk assessments were performed. There were 12,738 patients included, out of which 3702 were exposed to beta-blockers vs. 9036 non-exposed patients. Age, male sex, Breslow thickness, ulceration, and nodal status were independent negative prognostic factors for melanoma-specific survival (MSS). Adding beta-blockers to the analysis did not add any prognostic value to the model (HR 1.00, <i>p</i> = 0.98), neither when adjusting for competing risks (HR 0.97, <i>p</i> = 0.61). When specifically analyzing the use of non-selective beta-blockers, the results were still without statistical significance (HR 0.76, <i>p</i> = 0.21). In conclusion, this population-based registry study could not verify that the use of beta-adrenergic blocking agents improve survival in patients with melanoma.https://www.mdpi.com/2072-6694/12/11/3228melanomabeta blocking agentssurvival |
| spellingShingle | Dimitrios Katsarelias Hanna Eriksson Rasmus Mikiver Isabelle Krakowski Jonas A. Nilsson Lars Ny Roger Olofsson Bagge The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma—A Nation-Wide Swedish Population-Based Retrospective Register Study Cancers melanoma beta blocking agents survival |
| title | The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma—A Nation-Wide Swedish Population-Based Retrospective Register Study |
| title_full | The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma—A Nation-Wide Swedish Population-Based Retrospective Register Study |
| title_fullStr | The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma—A Nation-Wide Swedish Population-Based Retrospective Register Study |
| title_full_unstemmed | The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma—A Nation-Wide Swedish Population-Based Retrospective Register Study |
| title_short | The Effect of Beta-Adrenergic Blocking Agents in Cutaneous Melanoma—A Nation-Wide Swedish Population-Based Retrospective Register Study |
| title_sort | effect of beta adrenergic blocking agents in cutaneous melanoma a nation wide swedish population based retrospective register study |
| topic | melanoma beta blocking agents survival |
| url | https://www.mdpi.com/2072-6694/12/11/3228 |
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