Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation study
Purpose: The main advantages of charged particle radiotherapy compared to conventional X-ray external beam radiotherapy are a better tumor conformality coupled with the capability of treating deep-seated radio-resistant tumors. This work investigates the possibility to use oxygen beams for hadron th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Medical Physics |
| Subjects: | |
| Online Access: | http://www.jmp.org.in/article.asp?issn=0971-6203;year=2019;volume=44;issue=4;spage=263;epage=269;aulast=Ying |
| _version_ | 1818855457937162240 |
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| author | C K Ying David Bolst Anatoly Rosenfeld Susanna Guatelli |
| author_facet | C K Ying David Bolst Anatoly Rosenfeld Susanna Guatelli |
| author_sort | C K Ying |
| collection | DOAJ |
| description | Purpose: The main advantages of charged particle radiotherapy compared to conventional X-ray external beam radiotherapy are a better tumor conformality coupled with the capability of treating deep-seated radio-resistant tumors. This work investigates the possibility to use oxygen beams for hadron therapy, as an alternative to carbon ions. Materials and Methods: Oxygen ions have the advantage of a higher relative biological effectiveness (RBE) and better conformality to the tumor target. This work describes the mixed radiation field produced by an oxygen beam in water and compares it to the one produced by a therapeutic carbon ion beam. The study has been performed using Geant4 simulations. The dose is calculated for incident carbon ions with energies of 162 MeV/u and 290 MeV/u, and oxygen ions with energies of 192 MeV/u and 245 MeV/u, and hence that the range of the primary oxygen ions projectiles in water was located at the same depth as the carbon ions. Results: The results show that the benefits of oxygen ions are more pronounced when using lower energies because of a slightly higher peak-to-entrance ratio, which allows either providing higher dose in tumor target or reducing it in the surrounding healthy tissues. It is observed that, per incident particle, oxygen ions deliver higher doses than carbon ions.Conclusions: This result coupled with the higher RBE shows that it may be possible to use a lower fluence of oxygen ions to achieve the same therapeutic dose in the patient as that obtained with carbon ion therapy. |
| first_indexed | 2024-12-19T08:08:55Z |
| format | Article |
| id | doaj.art-5457e591ed3f4fa596ff1d0b968735fd |
| institution | Directory Open Access Journal |
| issn | 0971-6203 1998-3913 |
| language | English |
| last_indexed | 2024-12-19T08:08:55Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Physics |
| spelling | doaj.art-5457e591ed3f4fa596ff1d0b968735fd2022-12-21T20:29:41ZengWolters Kluwer Medknow PublicationsJournal of Medical Physics0971-62031998-39132019-01-0144426326910.4103/jmp.JMP_40_19Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation studyC K YingDavid BolstAnatoly RosenfeldSusanna GuatelliPurpose: The main advantages of charged particle radiotherapy compared to conventional X-ray external beam radiotherapy are a better tumor conformality coupled with the capability of treating deep-seated radio-resistant tumors. This work investigates the possibility to use oxygen beams for hadron therapy, as an alternative to carbon ions. Materials and Methods: Oxygen ions have the advantage of a higher relative biological effectiveness (RBE) and better conformality to the tumor target. This work describes the mixed radiation field produced by an oxygen beam in water and compares it to the one produced by a therapeutic carbon ion beam. The study has been performed using Geant4 simulations. The dose is calculated for incident carbon ions with energies of 162 MeV/u and 290 MeV/u, and oxygen ions with energies of 192 MeV/u and 245 MeV/u, and hence that the range of the primary oxygen ions projectiles in water was located at the same depth as the carbon ions. Results: The results show that the benefits of oxygen ions are more pronounced when using lower energies because of a slightly higher peak-to-entrance ratio, which allows either providing higher dose in tumor target or reducing it in the surrounding healthy tissues. It is observed that, per incident particle, oxygen ions deliver higher doses than carbon ions.Conclusions: This result coupled with the higher RBE shows that it may be possible to use a lower fluence of oxygen ions to achieve the same therapeutic dose in the patient as that obtained with carbon ion therapy.http://www.jmp.org.in/article.asp?issn=0971-6203;year=2019;volume=44;issue=4;spage=263;epage=269;aulast=Yingcarbon ionscharged particle therapygeant 4monte carlo simulationoxygen ions |
| spellingShingle | C K Ying David Bolst Anatoly Rosenfeld Susanna Guatelli Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation study Journal of Medical Physics carbon ions charged particle therapy geant 4 monte carlo simulation oxygen ions |
| title | Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation study |
| title_full | Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation study |
| title_fullStr | Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation study |
| title_full_unstemmed | Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation study |
| title_short | Characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy: A Monte Carlo simulation study |
| title_sort | characterization of the mixed radiation field produced by carbon and oxygen ion beams of therapeutic energy a monte carlo simulation study |
| topic | carbon ions charged particle therapy geant 4 monte carlo simulation oxygen ions |
| url | http://www.jmp.org.in/article.asp?issn=0971-6203;year=2019;volume=44;issue=4;spage=263;epage=269;aulast=Ying |
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