Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety
A number of important fused heterocyclic systems have been prepared by the reaction of 4-((3,5-diamino-1H-pyrazol-4-yl)-diazenyl)-N-(thiazol-2-yl)-benzenesulfonamide with some bifunctional nucleophiles such as ethyl acetoacetate, acetylacetone or arylidenemalonononitrile derivatives to obtain pyrazo...
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2020-12-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/5007 |
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| author | Elsherbiny Hamdy El-Sayed Ahmed Ali Fadda Ahmed Mohamed El-Saadaney |
| author_facet | Elsherbiny Hamdy El-Sayed Ahmed Ali Fadda Ahmed Mohamed El-Saadaney |
| author_sort | Elsherbiny Hamdy El-Sayed |
| collection | DOAJ |
| description | A number of important fused heterocyclic systems have been prepared by the reaction of 4-((3,5-diamino-1H-pyrazol-4-yl)-diazenyl)-N-(thiazol-2-yl)-benzenesulfonamide with some bifunctional nucleophiles such as ethyl acetoacetate, acetylacetone or arylidenemalonononitrile derivatives to obtain pyrazolo[1,5-a]pyrimidine derivatives. The structures of the newly synthesized compounds were determined based on their IR, 1H and 13C NMR and mass spectroscopic data. Most of the compounds produced showed good antibacterial and antifungal activity. |
| first_indexed | 2024-12-22T06:46:07Z |
| format | Article |
| id | doaj.art-5458116d94db40d79b2a3c2460c864fa |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-22T06:46:07Z |
| publishDate | 2020-12-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-5458116d94db40d79b2a3c2460c864fa2022-12-21T18:35:17ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552020-12-016741024103410.17344/acsi.2019.5007922Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole MoietyElsherbiny Hamdy El-SayedAhmed Ali FaddaAhmed Mohamed El-SaadaneyA number of important fused heterocyclic systems have been prepared by the reaction of 4-((3,5-diamino-1H-pyrazol-4-yl)-diazenyl)-N-(thiazol-2-yl)-benzenesulfonamide with some bifunctional nucleophiles such as ethyl acetoacetate, acetylacetone or arylidenemalonononitrile derivatives to obtain pyrazolo[1,5-a]pyrimidine derivatives. The structures of the newly synthesized compounds were determined based on their IR, 1H and 13C NMR and mass spectroscopic data. Most of the compounds produced showed good antibacterial and antifungal activity.https://journals.matheo.si/index.php/ACSi/article/view/5007sulfathiazolebenzenesulfonamidepyrazoleantimicrobial evaluation |
| spellingShingle | Elsherbiny Hamdy El-Sayed Ahmed Ali Fadda Ahmed Mohamed El-Saadaney Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety Acta Chimica Slovenica sulfathiazole benzenesulfonamide pyrazole antimicrobial evaluation |
| title | Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety |
| title_full | Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety |
| title_fullStr | Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety |
| title_full_unstemmed | Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety |
| title_short | Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety |
| title_sort | synthesis and antimicrobial evaluation of some new pyrazolo 1 5 a pyrimidine and pyrazolo 1 5 c triazine derivatives containing sulfathiazole moiety |
| topic | sulfathiazole benzenesulfonamide pyrazole antimicrobial evaluation |
| url | https://journals.matheo.si/index.php/ACSi/article/view/5007 |
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