Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull

Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull

The bones of the cranial vault are formed directly from mesenchymal cells through intramembranous ossification rather than via a cartilage intermediate. Formation and growth of the skull bones involves the interaction of multiple cell-cell signaling pathways, with fibroblast growth factors (FGFs) an...

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Bibliographic Details
Main Authors: Linnea Schmidt, Aftab Taiyab, Vida Senkus Melvin, Kenneth L. Jones, Trevor Williams
Format: Article
Language:English
Published: The Company of Biologists 2018-06-01
Series:Disease Models & Mechanisms
Subjects:
Intramembranous ossification
Fgf8
Cranial vault
Craniosynostosis
Osteogenesis
Chondrogenesis
Online Access:http://dmm.biologists.org/content/11/6/dmm031526

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