Design, Synthesis and Biological Evaluation of (2′,5′ and 3′5′-Linked) cGAMP Analogs that Activate Stimulator of Interferon Genes (STING)

Design, Synthesis and Biological Evaluation of (2′,5′ and 3′5′-Linked) cGAMP Analogs that Activate Stimulator of Interferon Genes (STING)

Stimulator of interferon genes (STING) is an endoplasmic reticulum adaptor transmembrane protein that plays a pivotal role in innate immune system. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse clinical research for immunogenic tumor c...

Full description

Bibliographic Details
Main Authors: Xin Xie, Junyi Liu, Xiaowei Wang
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
STING agonist
cyclic dinucleotides (CDNs)
SPR
immunotherapy
Online Access:https://www.mdpi.com/1420-3049/25/22/5285

Similar Items

Similar Items