Kunitz-Type Peptides from the Sea Anemone <i>Heteractis crispa</i> Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities

Kunitz-Type Peptides from the Sea Anemone <i>Heteractis crispa</i> Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities

The Kunitz/BPTI peptide family includes unique representatives demonstrating various biological activities. Electrophysiological screening of peptides HCRG1 and HCRG2 from the sea anemone <i>Heteractis crispa</i> on six Kv1.x channel isoforms and insect <i>Shaker</i> IR chann...

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Bibliographic Details
Main Authors: Irina Gladkikh, Steve Peigneur, Oksana Sintsova, Ernesto Lopes Pinheiro-Junior, Anna Klimovich, Alexander Menshov, Anatoly Kalinovsky, Marina Isaeva, Margarita Monastyrnaya, Emma Kozlovskaya, Jan Tytgat, Elena Leychenko
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomedicines
Subjects:
sea anemone
Kunitz fold
type 2 potassium channel toxins
electrophysiology
anti-inflammatory activity
Online Access:https://www.mdpi.com/2227-9059/8/11/473

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https://www.mdpi.com/2227-9059/8/11/473

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