Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysis
Introduction In responders, cardiac resynchronisation therapy (CRT) results in improved left ventricular (LV) function and reduced atrial arrhythmia. The aim of this meta-analysis was to assess the potential relationship between the left atrium (LA) volume and CRT response. Material and methods We...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2020-01-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Left-atrial-volume-index-predicts-response-to-cardiac-resynchronisation-therapy-a,108488,0,2.html |
| _version_ | 1797435314286886912 |
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| author | Ibadete Bytyçi Gani Bajraktari Michael Y. Henein |
| author_facet | Ibadete Bytyçi Gani Bajraktari Michael Y. Henein |
| author_sort | Ibadete Bytyçi |
| collection | DOAJ |
| description | Introduction
In responders, cardiac resynchronisation therapy (CRT) results in improved left ventricular (LV) function and reduced atrial arrhythmia. The aim of this meta-analysis was to assess the potential relationship between the left atrium (LA) volume and CRT response.
Material and methods
We systematically searched all electronic databases up to August 2018 in order to select clinical trials and observational studies that assessed the predictive value of LA volume index (LAVI) of CRT response. Left ventricular end-systolic volume (LVESV) reduction ≥ 15 ml and/or LV ejection fraction (EF) increase ≥ 10% were the documented criteria for positive CRT response.
Results
A total of 2191 patients recruited in 10 studies with mean follow-up duration of 10.5 months were included in this meta-analysis. The pooled analysis showed that CRT responders had lower baseline LAVI compared to non-responders, with a weighted mean difference (WMD) of –5.89% (95% CI: –9.47 to –3.22, p < 0.001). At follow-up, LAVI fell in the CRT responders (WMD –4.36%, 95% CI: –3.54 to –5.17, p < 0.001) compared to non-responders (WMD 1.45 %, 95% CI: –0.75 to 3.65, p = 0.20). The mean change of LAVI in the CRT responders was related to the fall in LVESV, = –1.02 (–1.46 to –0.58), p < 0.001 and the increase in LVEF, = 2.02 (1.86 to 4.58), p = 0.001. A baseline LAVI 11.
Conclusions
Baseline LAVI predicts CRT response, and its reduction reflects devise-related LA remodelling. These results emphasis the role of LAVI assessment as an integral part of cardiac function response to CRT. |
| first_indexed | 2024-03-09T10:46:22Z |
| format | Article |
| id | doaj.art-545d01a3ff3d4541ab6ca7d60963b0ad |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:46:22Z |
| publishDate | 2020-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-545d01a3ff3d4541ab6ca7d60963b0ad2023-12-01T10:02:33ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512020-01-0118493093810.5114/aoms.2019.91511108488Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysisIbadete Bytyçi0Gani Bajraktari1Michael Y. Henein2Institute of Public Health and Clinical Medicine, Umeå University, SwedenInstitute of Public Health and Clinical Medicine, Umeå University, SwedenInstitute of Public Health and Clinical Medicine, Umeå University, SwedenIntroduction In responders, cardiac resynchronisation therapy (CRT) results in improved left ventricular (LV) function and reduced atrial arrhythmia. The aim of this meta-analysis was to assess the potential relationship between the left atrium (LA) volume and CRT response. Material and methods We systematically searched all electronic databases up to August 2018 in order to select clinical trials and observational studies that assessed the predictive value of LA volume index (LAVI) of CRT response. Left ventricular end-systolic volume (LVESV) reduction ≥ 15 ml and/or LV ejection fraction (EF) increase ≥ 10% were the documented criteria for positive CRT response. Results A total of 2191 patients recruited in 10 studies with mean follow-up duration of 10.5 months were included in this meta-analysis. The pooled analysis showed that CRT responders had lower baseline LAVI compared to non-responders, with a weighted mean difference (WMD) of –5.89% (95% CI: –9.47 to –3.22, p < 0.001). At follow-up, LAVI fell in the CRT responders (WMD –4.36%, 95% CI: –3.54 to –5.17, p < 0.001) compared to non-responders (WMD 1.45 %, 95% CI: –0.75 to 3.65, p = 0.20). The mean change of LAVI in the CRT responders was related to the fall in LVESV, = –1.02 (–1.46 to –0.58), p < 0.001 and the increase in LVEF, = 2.02 (1.86 to 4.58), p = 0.001. A baseline LAVI 11. Conclusions Baseline LAVI predicts CRT response, and its reduction reflects devise-related LA remodelling. These results emphasis the role of LAVI assessment as an integral part of cardiac function response to CRT.https://www.archivesofmedicalscience.com/Left-atrial-volume-index-predicts-response-to-cardiac-resynchronisation-therapy-a,108488,0,2.htmlcardiac resynchronisation therapyleft atrial volume indexcardiac resynchronisation therapy responderscardiac resynchronisation therapy non-responders |
| spellingShingle | Ibadete Bytyçi Gani Bajraktari Michael Y. Henein Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysis Archives of Medical Science cardiac resynchronisation therapy left atrial volume index cardiac resynchronisation therapy responders cardiac resynchronisation therapy non-responders |
| title | Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysis |
| title_full | Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysis |
| title_fullStr | Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysis |
| title_full_unstemmed | Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysis |
| title_short | Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysis |
| title_sort | left atrial volume index predicts response to cardiac resynchronisation therapy a systematic review and meta analysis |
| topic | cardiac resynchronisation therapy left atrial volume index cardiac resynchronisation therapy responders cardiac resynchronisation therapy non-responders |
| url | https://www.archivesofmedicalscience.com/Left-atrial-volume-index-predicts-response-to-cardiac-resynchronisation-therapy-a,108488,0,2.html |
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