Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis
Abstract Background Outcome prediction for patients with sepsis may be conductive to early aggressive interventions. Numerous biomarkers and multiple scoring systems have been utilized in predicting outcomes, however, these tools were either expensive or inconvenient. We performed a meta-analysis to...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | BMC Immunology |
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| Online Access: | http://link.springer.com/article/10.1186/s12865-020-00369-6 |
| _version_ | 1818200986068451328 |
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| author | Lin Zhang Cui-hua Yu Kuan-peng Guo Cai-zhi Huang Li-ya Mo |
| author_facet | Lin Zhang Cui-hua Yu Kuan-peng Guo Cai-zhi Huang Li-ya Mo |
| author_sort | Lin Zhang |
| collection | DOAJ |
| description | Abstract Background Outcome prediction for patients with sepsis may be conductive to early aggressive interventions. Numerous biomarkers and multiple scoring systems have been utilized in predicting outcomes, however, these tools were either expensive or inconvenient. We performed a meta-analysis to evaluate the prognostic role of red blood cell distribution width (RDW) in patients with sepsis. Methods The online databases of Embase, Web of science, Pubmed, Corchrane library, Chinese Wanfang database, CNKI database were systematically searched from the inception dates to June, 24th, 2020, using the keywords red cell distribution width and sepsis. The odds ratio (OR) or Hazards ratio (HR) with corresponding 95% confidence intervals (95%CI) were pooled to evaluate the association between baseline RDW and sepsis. A random-effects model was used to pool the data, and statistical heterogeneity between studies was evaluated using the I 2 statistic. Sensitivity and subgroup analyses were performed to detect the publication bias and origin of heterogeneity. Results Eleven studies with 17,961 patients with sepsis were included in the meta-analysis. The pooled analyses indicated that increased baseline RDW was associated with mortality (HR = 1.14, 95%CI 1.09–1.20, Z = 5.78, P < 0.001) with significant heterogeneity (I 2 = 80%, P heterogeneity < 0.001). Similar results were found in the subgroup analysis stratified by site of infection, comorbidity, Newcastle-Ottawa Scale (NOS) score, study design, patients’ country. The predefined subgroup analysis showed that NOS score may be the origin of heterogeneity. Conclusions For patients with sepsis, baseline RDW may be a useful predictor of mortality, patients with increased RDW are more likely to have higher mortality. |
| first_indexed | 2024-12-12T02:46:22Z |
| format | Article |
| id | doaj.art-545d44443d8d43bc93f101422a1f4322 |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-12-12T02:46:22Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-545d44443d8d43bc93f101422a1f43222022-12-22T00:41:01ZengBMCBMC Immunology1471-21722020-07-012111810.1186/s12865-020-00369-6Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysisLin Zhang0Cui-hua Yu1Kuan-peng Guo2Cai-zhi Huang3Li-ya Mo4Department of clinical laboratory, Hunan children’s hospitalDepartment of GCP certified sites, The third hospital of Changsha CityDepartment of clinical laboratory, Hunan children’s hospitalDepartment of clinical laboratory, Hunan children’s hospitalDepartment of clinical laboratory, Hunan children’s hospitalAbstract Background Outcome prediction for patients with sepsis may be conductive to early aggressive interventions. Numerous biomarkers and multiple scoring systems have been utilized in predicting outcomes, however, these tools were either expensive or inconvenient. We performed a meta-analysis to evaluate the prognostic role of red blood cell distribution width (RDW) in patients with sepsis. Methods The online databases of Embase, Web of science, Pubmed, Corchrane library, Chinese Wanfang database, CNKI database were systematically searched from the inception dates to June, 24th, 2020, using the keywords red cell distribution width and sepsis. The odds ratio (OR) or Hazards ratio (HR) with corresponding 95% confidence intervals (95%CI) were pooled to evaluate the association between baseline RDW and sepsis. A random-effects model was used to pool the data, and statistical heterogeneity between studies was evaluated using the I 2 statistic. Sensitivity and subgroup analyses were performed to detect the publication bias and origin of heterogeneity. Results Eleven studies with 17,961 patients with sepsis were included in the meta-analysis. The pooled analyses indicated that increased baseline RDW was associated with mortality (HR = 1.14, 95%CI 1.09–1.20, Z = 5.78, P < 0.001) with significant heterogeneity (I 2 = 80%, P heterogeneity < 0.001). Similar results were found in the subgroup analysis stratified by site of infection, comorbidity, Newcastle-Ottawa Scale (NOS) score, study design, patients’ country. The predefined subgroup analysis showed that NOS score may be the origin of heterogeneity. Conclusions For patients with sepsis, baseline RDW may be a useful predictor of mortality, patients with increased RDW are more likely to have higher mortality.http://link.springer.com/article/10.1186/s12865-020-00369-6Red cell distribution widthSepsisSeptic shockMortalityMeta-analysis |
| spellingShingle | Lin Zhang Cui-hua Yu Kuan-peng Guo Cai-zhi Huang Li-ya Mo Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis BMC Immunology Red cell distribution width Sepsis Septic shock Mortality Meta-analysis |
| title | Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis |
| title_full | Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis |
| title_fullStr | Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis |
| title_short | Prognostic role of red blood cell distribution width in patients with sepsis: a systematic review and meta-analysis |
| title_sort | prognostic role of red blood cell distribution width in patients with sepsis a systematic review and meta analysis |
| topic | Red cell distribution width Sepsis Septic shock Mortality Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12865-020-00369-6 |
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