Aberrant Signaling Pathways in Glioma
Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/3/3242/ |
| _version_ | 1797710564577771520 |
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| author | Mitsutoshi Nakada Daisuke Kita Takuya Watanabe Yutaka Hayashi Jun-Ichiro Hamada Ilya V. Pyko Lei Teng |
| author_facet | Mitsutoshi Nakada Daisuke Kita Takuya Watanabe Yutaka Hayashi Jun-Ichiro Hamada Ilya V. Pyko Lei Teng |
| author_sort | Mitsutoshi Nakada |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology and clinical behavior of GBM. An integrated view of signal transduction will provide a more useful approach in designing novel therapies for this devastating disease. In this review, we summarize the current understanding of GBM signaling pathways with a focus on potential molecular targets for anti-signaling molecular therapies. |
| first_indexed | 2024-03-12T06:54:01Z |
| format | Article |
| id | doaj.art-545dc6259489484dbc7a15b2c97ea787 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:54:01Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-545dc6259489484dbc7a15b2c97ea7872023-09-03T00:07:39ZengMDPI AGCancers2072-66942011-08-01333242327810.3390/cancers3033242Aberrant Signaling Pathways in GliomaMitsutoshi NakadaDaisuke KitaTakuya WatanabeYutaka HayashiJun-Ichiro HamadaIlya V. PykoLei TengGlioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology and clinical behavior of GBM. An integrated view of signal transduction will provide a more useful approach in designing novel therapies for this devastating disease. In this review, we summarize the current understanding of GBM signaling pathways with a focus on potential molecular targets for anti-signaling molecular therapies.http://www.mdpi.com/2072-6694/3/3/3242/glioblastomasignalingproliferationinvasionangiogenesismolecular target |
| spellingShingle | Mitsutoshi Nakada Daisuke Kita Takuya Watanabe Yutaka Hayashi Jun-Ichiro Hamada Ilya V. Pyko Lei Teng Aberrant Signaling Pathways in Glioma Cancers glioblastoma signaling proliferation invasion angiogenesis molecular target |
| title | Aberrant Signaling Pathways in Glioma |
| title_full | Aberrant Signaling Pathways in Glioma |
| title_fullStr | Aberrant Signaling Pathways in Glioma |
| title_full_unstemmed | Aberrant Signaling Pathways in Glioma |
| title_short | Aberrant Signaling Pathways in Glioma |
| title_sort | aberrant signaling pathways in glioma |
| topic | glioblastoma signaling proliferation invasion angiogenesis molecular target |
| url | http://www.mdpi.com/2072-6694/3/3/3242/ |
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