Computational and Rational Design of Single-Chain Antibody against Tick-Borne Encephalitis Virus for Modifying Its Specificity

Computational and Rational Design of Single-Chain Antibody against Tick-Borne Encephalitis Virus for Modifying Its Specificity

Tick-borne encephalitis virus (TBEV) causes 5−7 thousand cases of human meningitis and encephalitis annually. The neutralizing and protective antibody ch14D5 is a potential therapeutic agent. This antibody exhibits a high affinity for binding with the D3 domain of the glycoprotein E of the Far Easte...

Full description

Bibliographic Details
Main Authors:	Ivan K. Baykov, Pavel Y. Desyukevich, Ekaterina E. Mikhaylova, Olga M. Kurchenko, Nina V. Tikunova
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Viruses
Subjects:	antibody tick-borne encephalitis virus rational design computational design modeling
Online Access:	https://www.mdpi.com/1999-4915/13/8/1494

Similar Items

Tick-Borne Encephalitis, Lombardy, Italy
by: Alessandra Gaffuri, et al.
Published: (2024-02-01)

Chimeric Antibody 14D5 Protects Mice against the Far-Eastern, Siberian, and European Tick-borne Encephalitis Virus
by: Andrey L. Matveev, et al.
Published: (2019-04-01)

Effectiveness of Specific Prevention of Tick-Borne Encephalitis
by: M. S. Shcherbinina, et al.
Published: (2020-09-01)

First Human Case of Tick-Borne Encephalitis in Non-Endemic Region in Italy: A Case Report
by: Nicole Barp, et al.
Published: (2022-07-01)

ON MODERN APPROACHES TO CREATION OF A SINGLE-CYCLE VACCINE AGAINST TICK-BORNE ENCEPHALITIS
by: V. A. Lashkevich, et al.
Published: (2018-06-01)

New Neutralizing Epitope Exposed on the Domain II of Tick-Borne Encephalitis Virus Envelope Glycoprotein E
by: Andrey Matveev, et al.
Published: (2023-05-01)

Epidemiological Trends of Trans-Boundary Tick-Borne Encephalitis in Europe, 2000–2019
by: Mulugeta A. Wondim, et al.
Published: (2022-06-01)

Combination therapy for the focal form of mixed tick-borne encephalitis-Borrelia infection
by: D. A. Etenko, et al.
Published: (2016-11-01)

Tick-borne encephalitis in Japan, Republic of Korea and China<subtitle>TBE in Japan, ROK and China</subtitle>
by: Kentaro Yoshii, et al.
Published: (2017-01-01)

The Prevalence of Asymptomatic Infections with Tick-Borne Encephalitis Virus and Attitude towards Tick-Borne Encephalitis Vaccine in the Endemic Area of Northeastern Poland
by: Ewa Bojkiewicz, et al.
Published: (2022-08-01)

Results of Tick-Borne Encephalitis Virus (TBEV) Diagnostics in an Endemic Area in Southern Germany, 2007 to 2022
by: Philipp Steininger, et al.
Published: (2023-11-01)

RESULTS OF GENOTYPING OF STRAINS AND RNA ISOLATES OF TICK-BORNE ENCEPHALITIS VIRUS ISOLATED FROM SICK PEOPLE IN IRKUTSK REGION AND BURYAT REPUBLIC
by: I. V. Kozlova, et al.
Published: (2012-09-01)

THE PREVALENCE OF TICK-BORNE ENCEPHALITIS VIRUS ANTIGEN IN SERUM SAMPLES FROM PEOPLE SUFFERED FROM TICK BITES
by: A^. .. Liapunov, et al.
Published: (2013-04-01)

COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE
by: N. V. Krylova, et al.
Published: (2014-07-01)

Fatal Case of Imported Tick-Borne Encephalitis in South Serbia
by: Lidija Popović Dragonjić, et al.
Published: (2022-12-01)

Analysis of Multiple Risk Factors for Seronegative Rate of Anti-Tick-Borne Encephalitis Virus Immunization in Human Serum
by: Marta Janik, et al.
Published: (2020-05-01)

THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE
by: M. V. Mesentseva, et al.
Published: (2014-07-01)

Tick-Borne Encephalitis in Kazakhstan: A Case Report
by: Saule Maukayeva, et al.
Published: (2020-04-01)

Tick-Borne Encephalitis—Review of the Current Status
by: Malgorzata Kwasnik, et al.
Published: (2023-10-01)

MRI Evolution of a Patient with Viral Tick-Borne Encephalitis and Polymorphic Seizures
by: Carmen Adella Sirbu, et al.
Published: (2022-08-01)

Tick-borne encephalitis as a trigger for anti-N-Methyl-d-aspartate receptor encephalitis
by: Thomas Agerbo Gaist, et al.
Published: (2024-03-01)

Tick-Borne Encephalitis in Pregnant Woman and Long-Term Sequelae
by: Aurélie Velay, et al.
Published: (2023-03-01)

Incidence of Tick-Borne Encephalitis during the COVID-19 Pandemic in Selected European Countries
by: Zbigniew Zając, et al.
Published: (2022-02-01)

Tick-Borne Encephalitis Virus Prevalence in Sheep, Wild Boar and Ticks in Belgium
by: Nadjah Radia Adjadj, et al.
Published: (2022-10-01)

T Cells in Tick-Borne Flavivirus Encephalitis: A Review of Current Paradigms in Protection and Disease Pathology
by: E. Taylor Stone, et al.
Published: (2023-04-01)

CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
by: I. V. Kozlova, et al.
Published: (2018-07-01)

Association between leukocyte telomere length and specific antibody levels after vaccination against tick-borne encephalitis
by: N. S. Yudin, et al.
Published: (2020-01-01)

Vaccination against Tick-Borne Encephalitis (TBE) in Italy: Still a Long Way to Go
by: Donatella Panatto, et al.
Published: (2022-02-01)

ROLE OF HUMORAL IMMUNE FACTORS IN ELIMINATION OF TICK-BORNE ENCEPHALITIS VIRUS IN NON-VACCINATED PERSONS, AND IN THOSE VACCINATED AGAINST TICK-BORNE ENCEPHALITIS
by: N. V. Krylova, et al.
Published: (2014-07-01)

A chronic form of tick-borne encephalitis. Case report
by: Ekaterina S. Ostapchuk, et al.
Published: (2024-01-01)

Commitment of Parents and Doctors of Irkutsk City to Vaccination against Tick-Borne Encephalitis
by: E. D. Kazantseva, et al.
Published: (2021-01-01)

New and Confirmed Foci of Tick-Borne Encephalitis Virus (TBEV) in Northern Germany Determined by TBEV Detection in Ticks
by: Anna-Katharina Topp, et al.
Published: (2022-01-01)

Modern nosoareas of tick-borne encephalitis and tick-borne rickettsiosis in Siberia
by: V. K. Yastrebov
Published: (2006-12-01)

Assessment of registered and hidden epidemic process of tick-borne encephalitis in the Republic of Karelia
by: Lyudmila V. Rubis, et al.
Published: (2024-01-01)

Cross-Reactive Antibodies in Tick-Borne Encephalitis: Case Report and Literature Review
by: Tatjana Vilibic-Cavlek, et al.
Published: (2022-11-01)

Comprehensive assessment of specific antibodies on infectious activity of tick-borne encephalitis virus
by: G. N. Leonova, et al.
Published: (2019-11-01)

Ecological and epidemiological characteristics of tick-borne encephalitis in St. Petersburg
by: E. A. Siuziumova, et al.
Published: (2020-08-01)

A case of combined infection with tick-borne encephalitis and lyme borreliosis with severe meningoencephalitis and complete recovery
by: Yekaterina O Ostapchuk, et al.
Published: (2023-01-01)

First evidence of tick-borne encephalitis (TBE) outside of Hokkaido Island in Japan
by: Masayuki Ohira, et al.
Published: (2023-12-01)

Experimental and Natural Infections of Tick-Borne Encephalitis Virus in Dogs
by: Jiri Salat, et al.
Published: (2021-10-01)