108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sample
OBJECTIVES/GOALS: To examine the relationship between chronic cadmium exposure and cognitive function in later life, we estimated the association of urinary cadmium concentration on composite cognitive score, an important marker of progression toward dementia, while accounting for diet and key co-po...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-04-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866122000280/type/journal_article |
| _version_ | 1811155216196698112 |
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| author | Tara E. Jenson Kelly M. Bakulski Keith Dookeran Ira Driscoll Amy E. Kalkbrenner |
| author_facet | Tara E. Jenson Kelly M. Bakulski Keith Dookeran Ira Driscoll Amy E. Kalkbrenner |
| author_sort | Tara E. Jenson |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: To examine the relationship between chronic cadmium exposure and cognitive function in later life, we estimated the association of urinary cadmium concentration on composite cognitive score, an important marker of progression toward dementia, while accounting for diet and key co-pollutants tobacco use and lead exposure. METHODS/STUDY POPULATION: After excluding those missing cognitive data (141) or covariate data (190), we included 760 persons >/= 60 years of age from the National Health and Nutrition Examination Survey (NHANES), 2011-2014. Urinary cadmium reflects prolonged exposure: mean=0.41μg/L (standard deviation (SD)= 0.46μg/L). Concurrent with urine sampling, neuropsychological tests tapping memory, executive function, sustained attention and working memory were combined into a standardized z-score (mean 0, SD 1, 25th and 75th percentiles −0.68 and 0.72, respectively). We used linear models to estimate change in cognition per cadmium interquartile range, incorporating NHANES sampling weights, adjusting for demographic characteristics, diet, lead, and active tobacco use (classified by self-report or serum cotinine levels >10ng/mL). RESULTS/ANTICIPATED RESULTS: A baseline model showed that an IQR (0.38 μg/L) increase in urinary cadmium exposure was associated with a 13% standard deviation lower cognitive z-score (95%CI: −0.19, −0.06), after adjusting for sampling weight and urinary creatinine (measure of urine dilution). This association was attenuated to 7% standard deviation lower cognitive z-score (95% CI −0.13, −0.02) after adjusting additionally for demographic characteristic of sex, age, age^2, race/ethnicity, marital status, education level, and poverty income ratio. Models further adjusted for smoking status (active/former/never), blood lead concentration, and key dietary sources of cadmium showed IQR increase in urinary cadmium exposure associated with 7% standard deviation lower cognitive z-score (95%CI: −0.14, −0.01). DISCUSSION/SIGNIFICANCE: Our findings suggest cadmium exposure is associated with lower cognitive scores even after accounting for confounding influence of diet, tobacco use and lead exposure. Alternate explanations include selection bias due to dropping persons missing needed variables and using concurrent cognitive measures rather than cognitive measures of over time. |
| first_indexed | 2024-04-10T04:30:26Z |
| format | Article |
| id | doaj.art-54603592b18d46268d386be1601307b6 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:30:26Z |
| publishDate | 2022-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-54603592b18d46268d386be1601307b62023-03-10T07:53:49ZengCambridge University PressJournal of Clinical and Translational Science2059-86612022-04-0162310.1017/cts.2022.28108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sampleTara E. Jenson0Kelly M. Bakulski1Keith Dookeran2Ira Driscoll3Amy E. Kalkbrenner4University of Wisconsin – MilwaukeeUniversity of MichiganUniversity of Wisconsin – MilwaukeeUniversity of Wisconsin – MilwaukeeUniversity of Wisconsin – MilwaukeeOBJECTIVES/GOALS: To examine the relationship between chronic cadmium exposure and cognitive function in later life, we estimated the association of urinary cadmium concentration on composite cognitive score, an important marker of progression toward dementia, while accounting for diet and key co-pollutants tobacco use and lead exposure. METHODS/STUDY POPULATION: After excluding those missing cognitive data (141) or covariate data (190), we included 760 persons >/= 60 years of age from the National Health and Nutrition Examination Survey (NHANES), 2011-2014. Urinary cadmium reflects prolonged exposure: mean=0.41μg/L (standard deviation (SD)= 0.46μg/L). Concurrent with urine sampling, neuropsychological tests tapping memory, executive function, sustained attention and working memory were combined into a standardized z-score (mean 0, SD 1, 25th and 75th percentiles −0.68 and 0.72, respectively). We used linear models to estimate change in cognition per cadmium interquartile range, incorporating NHANES sampling weights, adjusting for demographic characteristics, diet, lead, and active tobacco use (classified by self-report or serum cotinine levels >10ng/mL). RESULTS/ANTICIPATED RESULTS: A baseline model showed that an IQR (0.38 μg/L) increase in urinary cadmium exposure was associated with a 13% standard deviation lower cognitive z-score (95%CI: −0.19, −0.06), after adjusting for sampling weight and urinary creatinine (measure of urine dilution). This association was attenuated to 7% standard deviation lower cognitive z-score (95% CI −0.13, −0.02) after adjusting additionally for demographic characteristic of sex, age, age^2, race/ethnicity, marital status, education level, and poverty income ratio. Models further adjusted for smoking status (active/former/never), blood lead concentration, and key dietary sources of cadmium showed IQR increase in urinary cadmium exposure associated with 7% standard deviation lower cognitive z-score (95%CI: −0.14, −0.01). DISCUSSION/SIGNIFICANCE: Our findings suggest cadmium exposure is associated with lower cognitive scores even after accounting for confounding influence of diet, tobacco use and lead exposure. Alternate explanations include selection bias due to dropping persons missing needed variables and using concurrent cognitive measures rather than cognitive measures of over time.https://www.cambridge.org/core/product/identifier/S2059866122000280/type/journal_article |
| spellingShingle | Tara E. Jenson Kelly M. Bakulski Keith Dookeran Ira Driscoll Amy E. Kalkbrenner 108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sample Journal of Clinical and Translational Science |
| title | 108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sample |
| title_full | 108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sample |
| title_fullStr | 108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sample |
| title_full_unstemmed | 108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sample |
| title_short | 108 Chronic cadmium exposure is associated with cognition among adults over age 60 in a representative US sample |
| title_sort | 108 chronic cadmium exposure is associated with cognition among adults over age 60 in a representative us sample |
| url | https://www.cambridge.org/core/product/identifier/S2059866122000280/type/journal_article |
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