Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy
Progesterone is a gonadal pro-gestational hormone that is absolutely necessary for the success of pregnancy. Most notable actions of progesterone are observed in the female reproductive organs, the uterus and the ovary. Acting through the nuclear progesterone receptor (PGR), progesterone prepares th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.846226/full |
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| author | Soo Hyun Ahn Sean L. Nguyen Sean L. Nguyen Tae Hoon Kim Jae-Wook Jeong Ripla Arora John P. Lydon Margaret G. Petroff Margaret G. Petroff Margaret G. Petroff |
| author_facet | Soo Hyun Ahn Sean L. Nguyen Sean L. Nguyen Tae Hoon Kim Jae-Wook Jeong Ripla Arora John P. Lydon Margaret G. Petroff Margaret G. Petroff Margaret G. Petroff |
| author_sort | Soo Hyun Ahn |
| collection | DOAJ |
| description | Progesterone is a gonadal pro-gestational hormone that is absolutely necessary for the success of pregnancy. Most notable actions of progesterone are observed in the female reproductive organs, the uterus and the ovary. Acting through the nuclear progesterone receptor (PGR), progesterone prepares the endometrium for implantation of the embryo. Interestingly, the maternal thymus also is a known expressor of Pgr; its absence is associated with murine pregnancy complications. However, the localization of its expression and its functional importance were not known. Here, we used a transgenic dual fluorescent reporter mouse model and genetic deletion of Pgr in Foxn1+ thymic epithelial cells (TEC) to demonstrate TEC-specific Pgr expression in pregnancy, especially in the cortex where thymocyte maturation occurs. Using our TEC-specific Pgr deletion mouse model, we demonstrate that TEC-specific Pgr is necessary for pregnancy-induced thymic involution in pregnancy. Our investigation reveals that PGR expression is upregulated in the cortical thymic epithelial cells during pregnancy, and that PGR expression is important for thymic involution during murine pregnancy. |
| first_indexed | 2024-12-12T16:40:43Z |
| format | Article |
| id | doaj.art-5461c4abbba14e4c9ca7422ce24c3542 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T16:40:43Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-5461c4abbba14e4c9ca7422ce24c35422022-12-22T00:18:35ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-04-011310.3389/fendo.2022.846226846226Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine PregnancySoo Hyun Ahn0Sean L. Nguyen1Sean L. Nguyen2Tae Hoon Kim3Jae-Wook Jeong4Ripla Arora5John P. Lydon6Margaret G. Petroff7Margaret G. Petroff8Margaret G. Petroff9Department of Pathobiology Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, United StatesInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United StatesCell and Molecular Biology Program, Michigan State University, East Lansing, MI, United StatesDepartment of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI, United StatesDepartment of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI, United StatesDepartment of Obstetrics, Gynecology, and Reproductive Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United StatesDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United StatesDepartment of Pathobiology Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, United StatesCell and Molecular Biology Program, Michigan State University, East Lansing, MI, United StatesDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, United StatesProgesterone is a gonadal pro-gestational hormone that is absolutely necessary for the success of pregnancy. Most notable actions of progesterone are observed in the female reproductive organs, the uterus and the ovary. Acting through the nuclear progesterone receptor (PGR), progesterone prepares the endometrium for implantation of the embryo. Interestingly, the maternal thymus also is a known expressor of Pgr; its absence is associated with murine pregnancy complications. However, the localization of its expression and its functional importance were not known. Here, we used a transgenic dual fluorescent reporter mouse model and genetic deletion of Pgr in Foxn1+ thymic epithelial cells (TEC) to demonstrate TEC-specific Pgr expression in pregnancy, especially in the cortex where thymocyte maturation occurs. Using our TEC-specific Pgr deletion mouse model, we demonstrate that TEC-specific Pgr is necessary for pregnancy-induced thymic involution in pregnancy. Our investigation reveals that PGR expression is upregulated in the cortical thymic epithelial cells during pregnancy, and that PGR expression is important for thymic involution during murine pregnancy.https://www.frontiersin.org/articles/10.3389/fendo.2022.846226/fullthymuspregnancyinvolutionfertilityprogesterone receptor (PGR) |
| spellingShingle | Soo Hyun Ahn Sean L. Nguyen Sean L. Nguyen Tae Hoon Kim Jae-Wook Jeong Ripla Arora John P. Lydon Margaret G. Petroff Margaret G. Petroff Margaret G. Petroff Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy Frontiers in Endocrinology thymus pregnancy involution fertility progesterone receptor (PGR) |
| title | Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy |
| title_full | Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy |
| title_fullStr | Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy |
| title_full_unstemmed | Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy |
| title_short | Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy |
| title_sort | nuclear progesterone receptor expressed by the cortical thymic epithelial cells dictates thymus involution in murine pregnancy |
| topic | thymus pregnancy involution fertility progesterone receptor (PGR) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.846226/full |
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