AUTOPHAGY IN PLASMODIUM, A MULTIFUNCTIONAL PATHWAY?
Autophagy is a catabolic process that normally utilizes the lysosome. The far-reaching implications of this system in disease are being increasingly understood. Studying autophagy is complicated by its role in cell survival and programmed cell death and the involvement of the canonical marker of aut...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-08-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037014600143 |
| _version_ | 1811254925132300288 |
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| author | Adelaide U.P. Hain Jürgen Bosch |
| author_facet | Adelaide U.P. Hain Jürgen Bosch |
| author_sort | Adelaide U.P. Hain |
| collection | DOAJ |
| description | Autophagy is a catabolic process that normally utilizes the lysosome. The far-reaching implications of this system in disease are being increasingly understood. Studying autophagy is complicated by its role in cell survival and programmed cell death and the involvement of the canonical marker of autophagy, Atg8/LC3, in numerous non-autophagic roles. The malaria parasite, Plasmodium, has conserved certain aspects of the autophagic machinery but for what purpose has long remained a mystery. Major advances have recently been gained and suggest a role for Atg8 in apicoplast maintenance, degradation of heme inside the food vacuole, and possibly trafficking of proteins or organelles outside the parasite membrane. Autophagy may also participate in programmed cell death under drug treatment or as a selective tool to limit parasite load. We review the current findings and discuss discrepancies in the field of autophagy in the Plasmodium parasite. |
| first_indexed | 2024-04-12T17:14:52Z |
| format | Article |
| id | doaj.art-54631c293ce44d94afe354a4a1d9bc56 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-04-12T17:14:52Z |
| publishDate | 2013-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-54631c293ce44d94afe354a4a1d9bc562022-12-22T03:23:41ZengElsevierComputational and Structural Biotechnology Journal2001-03702013-08-0181110.5936/csbj.201308002AUTOPHAGY IN PLASMODIUM, A MULTIFUNCTIONAL PATHWAY?Adelaide U.P. Hain0Jürgen Bosch1Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, United StatesDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, United StatesAutophagy is a catabolic process that normally utilizes the lysosome. The far-reaching implications of this system in disease are being increasingly understood. Studying autophagy is complicated by its role in cell survival and programmed cell death and the involvement of the canonical marker of autophagy, Atg8/LC3, in numerous non-autophagic roles. The malaria parasite, Plasmodium, has conserved certain aspects of the autophagic machinery but for what purpose has long remained a mystery. Major advances have recently been gained and suggest a role for Atg8 in apicoplast maintenance, degradation of heme inside the food vacuole, and possibly trafficking of proteins or organelles outside the parasite membrane. Autophagy may also participate in programmed cell death under drug treatment or as a selective tool to limit parasite load. We review the current findings and discuss discrepancies in the field of autophagy in the Plasmodium parasite.http://www.sciencedirect.com/science/article/pii/S2001037014600143PlasmodiumapicoplasthemeAtgdigestive vacuole |
| spellingShingle | Adelaide U.P. Hain Jürgen Bosch AUTOPHAGY IN PLASMODIUM, A MULTIFUNCTIONAL PATHWAY? Computational and Structural Biotechnology Journal Plasmodium apicoplast heme Atg digestive vacuole |
| title | AUTOPHAGY IN PLASMODIUM, A MULTIFUNCTIONAL PATHWAY? |
| title_full | AUTOPHAGY IN PLASMODIUM, A MULTIFUNCTIONAL PATHWAY? |
| title_fullStr | AUTOPHAGY IN PLASMODIUM, A MULTIFUNCTIONAL PATHWAY? |
| title_full_unstemmed | AUTOPHAGY IN PLASMODIUM, A MULTIFUNCTIONAL PATHWAY? |
| title_short | AUTOPHAGY IN PLASMODIUM, A MULTIFUNCTIONAL PATHWAY? |
| title_sort | autophagy in plasmodium a multifunctional pathway |
| topic | Plasmodium apicoplast heme Atg digestive vacuole |
| url | http://www.sciencedirect.com/science/article/pii/S2001037014600143 |
| work_keys_str_mv | AT adelaideuphain autophagyinplasmodiumamultifunctionalpathway AT jurgenbosch autophagyinplasmodiumamultifunctionalpathway |