New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis
Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollus...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/13/3/1389 |
| _version_ | 1828364821561606144 |
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| author | Michael P. Gotsbacher Peter Karuso |
| author_facet | Michael P. Gotsbacher Peter Karuso |
| author_sort | Michael P. Gotsbacher |
| collection | DOAJ |
| description | Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites. |
| first_indexed | 2024-04-14T05:22:26Z |
| format | Article |
| id | doaj.art-546329b87b99470e88c772b57f9a9fcd |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T05:22:26Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-546329b87b99470e88c772b57f9a9fcd2022-12-22T02:10:08ZengMDPI AGMarine Drugs1660-33972015-03-011331389140910.3390/md13031389md13031389New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalisMichael P. Gotsbacher0Peter Karuso1Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, AustraliaDepartment of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, AustraliaBioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites.http://www.mdpi.com/1660-3397/13/3/1389alkaloidbromotyrosinePseudoceratinaspongeTylodinaantibioticsmarine natural products |
| spellingShingle | Michael P. Gotsbacher Peter Karuso New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis Marine Drugs alkaloid bromotyrosine Pseudoceratina sponge Tylodina antibiotics marine natural products |
| title | New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis |
| title_full | New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis |
| title_fullStr | New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis |
| title_full_unstemmed | New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis |
| title_short | New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis |
| title_sort | new antimicrobial bromotyrosine analogues from the sponge pseudoceratina purpurea and its predator tylodina corticalis |
| topic | alkaloid bromotyrosine Pseudoceratina sponge Tylodina antibiotics marine natural products |
| url | http://www.mdpi.com/1660-3397/13/3/1389 |
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