Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response to several different hypertrophic agents such as norepinephrine, angiotensin II and endothelin-1. PLC activity results in the generation of diacylglycerol and inositol trisphosphate, which are downstr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/16/2488 |
| _version_ | 1797446470457098240 |
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| author | Paramjit S. Tappia Naranjan S. Dhalla |
| author_facet | Paramjit S. Tappia Naranjan S. Dhalla |
| author_sort | Paramjit S. Tappia |
| collection | DOAJ |
| description | The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response to several different hypertrophic agents such as norepinephrine, angiotensin II and endothelin-1. PLC activity results in the generation of diacylglycerol and inositol trisphosphate, which are downstream signal transducers for the expression of fetal genes, increased protein synthesis, and subsequent cardiomyocyte growth. In this article, we describe the signal transduction elements that regulate PLC gene expression. The discussion is focused on the norepinephrine- α<sub>1</sub>-adrenoceptor signaling pathway and downstream signaling processes that mediate an upregulation of PLC isozyme gene expression. Evidence is also indicated to demonstrate that PLC activities self-regulate the expression of PLC isozymes with the suggestion that PLC activities may be part of a coordinated signaling process for the perpetuation of cardiac hypertrophy. Accordingly, from the information provided, it is plausible that specific PLC isozymes could be targeted for the mitigation of cardiac hypertrophy. |
| first_indexed | 2024-03-09T13:41:17Z |
| format | Article |
| id | doaj.art-54637f6707dc478a9404bc1040cc6dc3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T13:41:17Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-54637f6707dc478a9404bc1040cc6dc32023-11-30T21:06:23ZengMDPI AGCells2073-44092022-08-011116248810.3390/cells11162488Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic ResponseParamjit S. Tappia0Naranjan S. Dhalla1Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, MB R2H 2A6, CanadaInstitute of Cardiovascular Sciences & Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaThe activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response to several different hypertrophic agents such as norepinephrine, angiotensin II and endothelin-1. PLC activity results in the generation of diacylglycerol and inositol trisphosphate, which are downstream signal transducers for the expression of fetal genes, increased protein synthesis, and subsequent cardiomyocyte growth. In this article, we describe the signal transduction elements that regulate PLC gene expression. The discussion is focused on the norepinephrine- α<sub>1</sub>-adrenoceptor signaling pathway and downstream signaling processes that mediate an upregulation of PLC isozyme gene expression. Evidence is also indicated to demonstrate that PLC activities self-regulate the expression of PLC isozymes with the suggestion that PLC activities may be part of a coordinated signaling process for the perpetuation of cardiac hypertrophy. Accordingly, from the information provided, it is plausible that specific PLC isozymes could be targeted for the mitigation of cardiac hypertrophy.https://www.mdpi.com/2073-4409/11/16/2488phospholipase C isozymescardiomyocytessignal transductioncardiac gene expressioncardiac cell growthcardiac hypertrophy |
| spellingShingle | Paramjit S. Tappia Naranjan S. Dhalla Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response Cells phospholipase C isozymes cardiomyocytes signal transduction cardiac gene expression cardiac cell growth cardiac hypertrophy |
| title | Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response |
| title_full | Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response |
| title_fullStr | Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response |
| title_full_unstemmed | Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response |
| title_short | Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response |
| title_sort | upregulation of phospholipase c gene expression due to norepinephrine induced hypertrophic response |
| topic | phospholipase C isozymes cardiomyocytes signal transduction cardiac gene expression cardiac cell growth cardiac hypertrophy |
| url | https://www.mdpi.com/2073-4409/11/16/2488 |
| work_keys_str_mv | AT paramjitstappia upregulationofphospholipasecgeneexpressionduetonorepinephrineinducedhypertrophicresponse AT naranjansdhalla upregulationofphospholipasecgeneexpressionduetonorepinephrineinducedhypertrophicresponse |