Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of Glabridin
Metal organic frameworks (MOFs) are formed by self-assembly of metal ions and organic ligands. A special type of MOF called ZIF-8, which is formed by self-assembly of zinc ions and 2-methylimidazole, shows excellent stability in aqueous solutions and disintegrates under acidic conditions. These prop...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/12/3908 |
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| author | Liang Chen Zexun Liu Xinying Zhao Linying Liu Xiulan Xin Hao Liang |
| author_facet | Liang Chen Zexun Liu Xinying Zhao Linying Liu Xiulan Xin Hao Liang |
| author_sort | Liang Chen |
| collection | DOAJ |
| description | Metal organic frameworks (MOFs) are formed by self-assembly of metal ions and organic ligands. A special type of MOF called ZIF-8, which is formed by self-assembly of zinc ions and 2-methylimidazole, shows excellent stability in aqueous solutions and disintegrates under acidic conditions. These properties make ZIF-8 a suitable carrier material for pH-stimulated drug delivery systems. Glabridin is an isoflavane compound that is widely present in the roots of <i>licorice</i>. Because of its outstanding skin whitening properties, glabridin is widely used as a whitener in the cosmetics industry. In this study, ZIF-8 was employed to encapsulate glabridin. Glabridin-loaded ZIF-8 was successfully prepared with a drug encapsulation efficiency of 98.67%. The prepared sample showed a fusiform or cruciate flower-like structure, and its size was about 3 μm. ZIF-8 enabled pH-controlled release of glabridin. Moreover, ZIF-8 encapsulation significantly enhanced the intracellular anti-oxidant activity and melanogenesis inhibitory activity of glabridin. This study provides a new approach that shows great potential to improve the biological application of glabridin. |
| first_indexed | 2024-03-09T22:54:07Z |
| format | Article |
| id | doaj.art-546425918a384d7ab4f2021207ef9494 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T22:54:07Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-546425918a384d7ab4f2021207ef94942023-11-23T18:13:34ZengMDPI AGMolecules1420-30492022-06-012712390810.3390/molecules27123908Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of GlabridinLiang Chen0Zexun Liu1Xinying Zhao2Linying Liu3Xiulan Xin4Hao Liang5College of Bioengineering, Beijing Polytechnic, Beijing 100176, ChinaState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaCollege of Bioengineering, Beijing Polytechnic, Beijing 100176, ChinaCollege of Bioengineering, Beijing Polytechnic, Beijing 100176, ChinaCollege of Bioengineering, Beijing Polytechnic, Beijing 100176, ChinaState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaMetal organic frameworks (MOFs) are formed by self-assembly of metal ions and organic ligands. A special type of MOF called ZIF-8, which is formed by self-assembly of zinc ions and 2-methylimidazole, shows excellent stability in aqueous solutions and disintegrates under acidic conditions. These properties make ZIF-8 a suitable carrier material for pH-stimulated drug delivery systems. Glabridin is an isoflavane compound that is widely present in the roots of <i>licorice</i>. Because of its outstanding skin whitening properties, glabridin is widely used as a whitener in the cosmetics industry. In this study, ZIF-8 was employed to encapsulate glabridin. Glabridin-loaded ZIF-8 was successfully prepared with a drug encapsulation efficiency of 98.67%. The prepared sample showed a fusiform or cruciate flower-like structure, and its size was about 3 μm. ZIF-8 enabled pH-controlled release of glabridin. Moreover, ZIF-8 encapsulation significantly enhanced the intracellular anti-oxidant activity and melanogenesis inhibitory activity of glabridin. This study provides a new approach that shows great potential to improve the biological application of glabridin.https://www.mdpi.com/1420-3049/27/12/3908self-assemblypH-controlled releasemetal organic frameworks (MOFs)glabridinencapsulationanti-oxidation |
| spellingShingle | Liang Chen Zexun Liu Xinying Zhao Linying Liu Xiulan Xin Hao Liang Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of Glabridin Molecules self-assembly pH-controlled release metal organic frameworks (MOFs) glabridin encapsulation anti-oxidation |
| title | Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of Glabridin |
| title_full | Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of Glabridin |
| title_fullStr | Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of Glabridin |
| title_full_unstemmed | Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of Glabridin |
| title_short | Self-Assembled pH-Responsive Metal-Organic Frameworks for Enhancing the Encapsulation and Anti-Oxidation and Melanogenesis Inhibition Activities of Glabridin |
| title_sort | self assembled ph responsive metal organic frameworks for enhancing the encapsulation and anti oxidation and melanogenesis inhibition activities of glabridin |
| topic | self-assembly pH-controlled release metal organic frameworks (MOFs) glabridin encapsulation anti-oxidation |
| url | https://www.mdpi.com/1420-3049/27/12/3908 |
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