Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review
Mesenchymal hamartoma of the liver (MHL) is a rare benign lesion occurring primarily in the pediatric population. While the precise pathogenesis of the tumor is not certain, the most common theory relates to aberrant mesenchyme development in the portal tract likely related to the bile ducts. A 53-y...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2010-03-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/260183 |
| _version_ | 1819209238646358016 |
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| author | Zachary Klaassen Prakash R. Paragi Ronald S. Chamberlain |
| author_facet | Zachary Klaassen Prakash R. Paragi Ronald S. Chamberlain |
| author_sort | Zachary Klaassen |
| collection | DOAJ |
| description | Mesenchymal hamartoma of the liver (MHL) is a rare benign lesion occurring primarily in the pediatric population. While the precise pathogenesis of the tumor is not certain, the most common theory relates to aberrant mesenchyme development in the portal tract likely related to the bile ducts. A 53-year-old female was evaluated for an incidental liver mass. Initial CT scan showed a cystic lesion in the right lobe of the liver and follow-up imaging revealed an increase in size and the percent solid component within the mass. In view of these changes, a nondiagnostic biopsy was obtained followed by extirpation of the lesion. Gross pathological review of the lesion identified a 9 × 9 × 7.5 cm, pink-yellow-tan, gelatinous mass, with a >1 cm clear surgical margin. Histologically, the mass consisted of benign dilated bile ducts, as well as myxoid stroma with spindle cells showing smooth muscle differentiation. The patient was discharged home on postoperative day five. A review of the literature for MHL in adults reports 30 previous cases, predominantly published as individual case reports describing the size, lobe(s) of the liver affected, and the cystic/solid nature of the tumor. MHL in adults may represent a potentially premalignant lesion, as the emerging literature supports a potential relationship between MHL and malignant undifferentiated embryonal sarcoma in regards to cytogenetic analysis. Aggressive surgical management of MHL in adults is mandated when feasible. |
| first_indexed | 2024-12-23T05:52:07Z |
| format | Article |
| id | doaj.art-54656b52434249ca99f53f7213326c4b |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-23T05:52:07Z |
| publishDate | 2010-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-54656b52434249ca99f53f7213326c4b2022-12-21T17:57:55ZengKarger PublishersCase Reports in Gastroenterology1662-06312010-03-0141849210.1159/000260183260183Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature ReviewZachary KlaassenPrakash R. ParagiRonald S. ChamberlainMesenchymal hamartoma of the liver (MHL) is a rare benign lesion occurring primarily in the pediatric population. While the precise pathogenesis of the tumor is not certain, the most common theory relates to aberrant mesenchyme development in the portal tract likely related to the bile ducts. A 53-year-old female was evaluated for an incidental liver mass. Initial CT scan showed a cystic lesion in the right lobe of the liver and follow-up imaging revealed an increase in size and the percent solid component within the mass. In view of these changes, a nondiagnostic biopsy was obtained followed by extirpation of the lesion. Gross pathological review of the lesion identified a 9 × 9 × 7.5 cm, pink-yellow-tan, gelatinous mass, with a >1 cm clear surgical margin. Histologically, the mass consisted of benign dilated bile ducts, as well as myxoid stroma with spindle cells showing smooth muscle differentiation. The patient was discharged home on postoperative day five. A review of the literature for MHL in adults reports 30 previous cases, predominantly published as individual case reports describing the size, lobe(s) of the liver affected, and the cystic/solid nature of the tumor. MHL in adults may represent a potentially premalignant lesion, as the emerging literature supports a potential relationship between MHL and malignant undifferentiated embryonal sarcoma in regards to cytogenetic analysis. Aggressive surgical management of MHL in adults is mandated when feasible.http://www.karger.com/Article/FullText/260183Hepatic massUndifferentiated embryonal sarcomaMesenchymal hamartomaHepatobiliary surgery |
| spellingShingle | Zachary Klaassen Prakash R. Paragi Ronald S. Chamberlain Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review Case Reports in Gastroenterology Hepatic mass Undifferentiated embryonal sarcoma Mesenchymal hamartoma Hepatobiliary surgery |
| title | Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review |
| title_full | Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review |
| title_fullStr | Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review |
| title_full_unstemmed | Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review |
| title_short | Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review |
| title_sort | adult mesenchymal hamartoma of the liver case report and literature review |
| topic | Hepatic mass Undifferentiated embryonal sarcoma Mesenchymal hamartoma Hepatobiliary surgery |
| url | http://www.karger.com/Article/FullText/260183 |
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