Hemophagocytic Lymphohistiocytosis Complicated by Acute Respiratory Distress Syndrome and Multiorgan Failure
Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition that is characterized by an overactive response of the immune system with excessive production of proinflammatory cytokines. Initial presentation of this condition often mimics and overlaps with many diseases including...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-11-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096211052180 |
| _version_ | 1819015258923073536 |
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| author | Louisa Liu MD Hanad Bashir MD Hassan Awada MD Jafar Alzubi MD Jason Lane MD |
| author_facet | Louisa Liu MD Hanad Bashir MD Hassan Awada MD Jafar Alzubi MD Jason Lane MD |
| author_sort | Louisa Liu MD |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition that is characterized by an overactive response of the immune system with excessive production of proinflammatory cytokines. Initial presentation of this condition often mimics and overlaps with many diseases including infections, sepsis, and multiorgan failure syndrome, which makes diagnosis the diagnosis of HLH challenging. Herein is described a case of a patient who developed acute respiratory distress syndrome and multiple organ failure related to HLH in a setting of probable viral pneumonia. The diagnosis was established based on laboratory and bone marrow biopsy findings. This patient was treated with the standard chemotherapy regimen of intravenous dexamethasone, etoposide in addition to intrathecal methotrexate for central nervous system involvement. |
| first_indexed | 2024-12-21T02:28:53Z |
| format | Article |
| id | doaj.art-546593dbc79d455d88678b868c35e456 |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-21T02:28:53Z |
| publishDate | 2021-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-546593dbc79d455d88678b868c35e4562022-12-21T19:18:58ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962021-11-01910.1177/23247096211052180Hemophagocytic Lymphohistiocytosis Complicated by Acute Respiratory Distress Syndrome and Multiorgan FailureLouisa Liu MD0Hanad Bashir MD1Hassan Awada MD2Jafar Alzubi MD3Jason Lane MD4University of California, Riverside, USAAkron General Health System, OH, USAAkron General Health System, OH, USAAkron General Health System, OH, USAAkron General Health System, OH, USAHemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition that is characterized by an overactive response of the immune system with excessive production of proinflammatory cytokines. Initial presentation of this condition often mimics and overlaps with many diseases including infections, sepsis, and multiorgan failure syndrome, which makes diagnosis the diagnosis of HLH challenging. Herein is described a case of a patient who developed acute respiratory distress syndrome and multiple organ failure related to HLH in a setting of probable viral pneumonia. The diagnosis was established based on laboratory and bone marrow biopsy findings. This patient was treated with the standard chemotherapy regimen of intravenous dexamethasone, etoposide in addition to intrathecal methotrexate for central nervous system involvement.https://doi.org/10.1177/23247096211052180 |
| spellingShingle | Louisa Liu MD Hanad Bashir MD Hassan Awada MD Jafar Alzubi MD Jason Lane MD Hemophagocytic Lymphohistiocytosis Complicated by Acute Respiratory Distress Syndrome and Multiorgan Failure Journal of Investigative Medicine High Impact Case Reports |
| title | Hemophagocytic Lymphohistiocytosis Complicated by Acute Respiratory Distress Syndrome and Multiorgan Failure |
| title_full | Hemophagocytic Lymphohistiocytosis Complicated by Acute Respiratory Distress Syndrome and Multiorgan Failure |
| title_fullStr | Hemophagocytic Lymphohistiocytosis Complicated by Acute Respiratory Distress Syndrome and Multiorgan Failure |
| title_full_unstemmed | Hemophagocytic Lymphohistiocytosis Complicated by Acute Respiratory Distress Syndrome and Multiorgan Failure |
| title_short | Hemophagocytic Lymphohistiocytosis Complicated by Acute Respiratory Distress Syndrome and Multiorgan Failure |
| title_sort | hemophagocytic lymphohistiocytosis complicated by acute respiratory distress syndrome and multiorgan failure |
| url | https://doi.org/10.1177/23247096211052180 |
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