The Role of DNA Repair in Genomic Instability of Multiple Myeloma
Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently, it has been reported that DNA repair can influence genomic changes and drug resistance...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/10/5688 |
| _version_ | 1797499153442406400 |
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| author | Jana Yasser Hafez Ali Amira Mohammed Fitieh Ismail Hassan Ismail |
| author_facet | Jana Yasser Hafez Ali Amira Mohammed Fitieh Ismail Hassan Ismail |
| author_sort | Jana Yasser Hafez Ali |
| collection | DOAJ |
| description | Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently, it has been reported that DNA repair can influence genomic changes and drug resistance in MM. The dysregulation of DNA repair function may provide an alternative explanation for genomic instability observed in MM cells and in cells derived from MM patients. This review provides an overview of DNA repair pathways with a special focus on their involvement in MM and discusses the role they play in MM progression and drug resistance. This review highlights how unrepaired DNA damage due to aberrant DNA repair response in MM exacerbates genomic instability and chromosomal abnormalities, enabling MM progression and drug resistance. |
| first_indexed | 2024-03-10T03:43:22Z |
| format | Article |
| id | doaj.art-546637ac35264e208d0e6e72e6065e42 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:43:22Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-546637ac35264e208d0e6e72e6065e422023-11-23T11:26:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012310568810.3390/ijms23105688The Role of DNA Repair in Genomic Instability of Multiple MyelomaJana Yasser Hafez Ali0Amira Mohammed Fitieh1Ismail Hassan Ismail2Biophysics Department, Faculty of Science, Cairo University, Giza 12613, EgyptBiophysics Department, Faculty of Science, Cairo University, Giza 12613, EgyptBiophysics Department, Faculty of Science, Cairo University, Giza 12613, EgyptMultiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently, it has been reported that DNA repair can influence genomic changes and drug resistance in MM. The dysregulation of DNA repair function may provide an alternative explanation for genomic instability observed in MM cells and in cells derived from MM patients. This review provides an overview of DNA repair pathways with a special focus on their involvement in MM and discusses the role they play in MM progression and drug resistance. This review highlights how unrepaired DNA damage due to aberrant DNA repair response in MM exacerbates genomic instability and chromosomal abnormalities, enabling MM progression and drug resistance.https://www.mdpi.com/1422-0067/23/10/5688multiple myelomaDNA repairgenomic instabilityDNA damage responsemyeloma therapeutics |
| spellingShingle | Jana Yasser Hafez Ali Amira Mohammed Fitieh Ismail Hassan Ismail The Role of DNA Repair in Genomic Instability of Multiple Myeloma International Journal of Molecular Sciences multiple myeloma DNA repair genomic instability DNA damage response myeloma therapeutics |
| title | The Role of DNA Repair in Genomic Instability of Multiple Myeloma |
| title_full | The Role of DNA Repair in Genomic Instability of Multiple Myeloma |
| title_fullStr | The Role of DNA Repair in Genomic Instability of Multiple Myeloma |
| title_full_unstemmed | The Role of DNA Repair in Genomic Instability of Multiple Myeloma |
| title_short | The Role of DNA Repair in Genomic Instability of Multiple Myeloma |
| title_sort | role of dna repair in genomic instability of multiple myeloma |
| topic | multiple myeloma DNA repair genomic instability DNA damage response myeloma therapeutics |
| url | https://www.mdpi.com/1422-0067/23/10/5688 |
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