<i>MLL</i>-Rearranged Acute Leukemia with t(4;11)(q21;q23)—Current Treatment Options. Is There a Role for CAR-T Cell Therapy?

<i>MLL</i>-Rearranged Acute Leukemia with t(4;11)(q21;q23)—Current Treatment Options. Is There a Role for CAR-T Cell Therapy?

The <i>MLL</i> (<i>mixed-lineage leukemia</i>) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately 10% of acute lymphoblastic leukemia and 2.8% of acute myeloid leukemia cases. These trans...

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Bibliographic Details
Main Authors: Oliver Britten, Denise Ragusa, Sabrina Tosi, Yasser Mostafa Kamel
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
<i>mll</i>
<i>mixed-lineage leukemia</i>
<i>kmt2a</i>
car-t cell therapy
acute leukemia
chromosome translocation
mll-af4
Online Access:https://www.mdpi.com/2073-4409/8/11/1341

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