Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models
Cancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type is the third most common cancer globally. Resveratrol (RSV) is a natural compound with an effective anticancer effect, especially against colorectal cancer, and therefore numerous studies recommended its us...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/6/1412 |
| _version_ | 1818038901628993536 |
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| author | Thangirala Sudha Ali H. El-Far Deena S. Mousa Shaker A. Mousa |
| author_facet | Thangirala Sudha Ali H. El-Far Deena S. Mousa Shaker A. Mousa |
| author_sort | Thangirala Sudha |
| collection | DOAJ |
| description | Cancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type is the third most common cancer globally. Resveratrol (RSV) is a natural compound with an effective anticancer effect, especially against colorectal cancer, and therefore numerous studies recommended its use in colorectal cancer prevention and treatment. The current study investigated the effect of either RSV or its nanoformulation (NP-RSV) on the growth and vascularity of xenograft and orthotopic mice models in colon cancer (COLO205-luc). Both RSV and NP-RSV induced significant reductions in tumor growth and the hemoglobin percentages of the tumor mass, but NP-RSV showed greater bioavailability and efficacy than RSV. Generally, we recommend using NP-RSV as a therapeutic to control colon cancer. |
| first_indexed | 2024-12-10T07:50:06Z |
| format | Article |
| id | doaj.art-546876c20cef44469a3722138bc4c002 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T07:50:06Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-546876c20cef44469a3722138bc4c0022022-12-22T01:57:04ZengMDPI AGMolecules1420-30492020-03-01256141210.3390/molecules25061412molecules25061412Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer ModelsThangirala Sudha0Ali H. El-Far1Deena S. Mousa2Shaker A. Mousa3Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USADepartment of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, EgyptJonathan Edwards College, Yale University, New Haven, CT 208220, USAPharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USACancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type is the third most common cancer globally. Resveratrol (RSV) is a natural compound with an effective anticancer effect, especially against colorectal cancer, and therefore numerous studies recommended its use in colorectal cancer prevention and treatment. The current study investigated the effect of either RSV or its nanoformulation (NP-RSV) on the growth and vascularity of xenograft and orthotopic mice models in colon cancer (COLO205-luc). Both RSV and NP-RSV induced significant reductions in tumor growth and the hemoglobin percentages of the tumor mass, but NP-RSV showed greater bioavailability and efficacy than RSV. Generally, we recommend using NP-RSV as a therapeutic to control colon cancer.https://www.mdpi.com/1420-3049/25/6/1412colon cancerresveratrolnanoformulationxenograftorthotopic model |
| spellingShingle | Thangirala Sudha Ali H. El-Far Deena S. Mousa Shaker A. Mousa Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models Molecules colon cancer resveratrol nanoformulation xenograft orthotopic model |
| title | Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models |
| title_full | Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models |
| title_fullStr | Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models |
| title_full_unstemmed | Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models |
| title_short | Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models |
| title_sort | resveratrol and its nanoformulation attenuate growth and the angiogenesis of xenograft and orthotopic colon cancer models |
| topic | colon cancer resveratrol nanoformulation xenograft orthotopic model |
| url | https://www.mdpi.com/1420-3049/25/6/1412 |
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