X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4<sup>+</sup> T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA

X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4<sup>+</sup> T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA

ABSTRACT Reversible repression of HIV-1 5′ long terminal repeat (5′-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency. Identification of host factors that modulate LTR activity and viral latency may help develop new antiretroviral therapies. The heterogeneous nu...

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Bibliographic Details
Main Authors: Li Ma, Qing-An Jiang, Li Sun, Xianguang Yang, Hai Huang, Xia Jin, Chiyu Zhang, Jian-Hua Wang
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
HIV-1
RBMX
transcription
H3K9me3
Online Access:https://journals.asm.org/doi/10.1128/mBio.03424-19

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