BronchUK: protocol for an observational cohort study and biobank in bronchiectasis
Bronchiectasis has been a largely overlooked disease area in respiratory medicine. This is reflected by a shortage of large-scale studies and lack of approved therapies, in turn leading to a variation of treatment across centres. BronchUK (Bronchiectasis Observational Cohort and Biobank UK) is a mul...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2021-04-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/7/2/00775-2020.full |
| _version_ | 1818924592425598976 |
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| author | Anthony De Soyza Philip Mawson Adam T. Hill Stuart Elborn Judy M. Bradley Charles S. Haworth R. Andres Floto Robert Wilson Michael R. Loebinger Mary Carroll Megan Crichton James D. Chalmers Anita Sullivan Jeremy Brown John R. Hurst Jamie Duckers Martin Kelly John Steer Tim Gatheral Paul P. Walker Craig Winstanley Alistair McGuire David Denning Richard McNally |
| author_facet | Anthony De Soyza Philip Mawson Adam T. Hill Stuart Elborn Judy M. Bradley Charles S. Haworth R. Andres Floto Robert Wilson Michael R. Loebinger Mary Carroll Megan Crichton James D. Chalmers Anita Sullivan Jeremy Brown John R. Hurst Jamie Duckers Martin Kelly John Steer Tim Gatheral Paul P. Walker Craig Winstanley Alistair McGuire David Denning Richard McNally |
| author_sort | Anthony De Soyza |
| collection | DOAJ |
| description | Bronchiectasis has been a largely overlooked disease area in respiratory medicine. This is reflected by a shortage of large-scale studies and lack of approved therapies, in turn leading to a variation of treatment across centres. BronchUK (Bronchiectasis Observational Cohort and Biobank UK) is a multicentre, prospective, observational cohort study working collaboratively with the European Multicentre Bronchiectasis Audit and Research Collaboration project. The inclusion criteria for patients entering the study are a clinical history consistent with bronchiectasis and computed tomography demonstrating bronchiectasis. Main exclusion criteria are 1) patients unable to provide informed consent, 2) bronchiectasis due to known cystic fibrosis or where bronchiectasis is not the main or co-dominant respiratory disease, 3) age <18 years, and 4) prior lung transplantation for bronchiectasis. The study is aligned to standard UK National Health Service (NHS) practice with an aim to recruit a minimum of 1500 patients from across at least nine secondary care centres. Patient data collected at baseline includes demographics, aetiology testing, comorbidities, lung function, radiology, treatments, microbiology and quality of life. Patients are followed up annually for a maximum of 5 years and, where able, blood and/or sputa samples are collected and stored in a central biobank. BronchUK aims to collect robust longitudinal data that can be used for analysis into current NHS practice and patient outcomes, and to become an integral resource to better inform future interventional studies in bronchiectasis. |
| first_indexed | 2024-12-20T02:27:47Z |
| format | Article |
| id | doaj.art-54698cb8547746ac8a06a7230fbcd6c9 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-12-20T02:27:47Z |
| publishDate | 2021-04-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-54698cb8547746ac8a06a7230fbcd6c92022-12-21T19:56:38ZengEuropean Respiratory SocietyERJ Open Research2312-05412021-04-017210.1183/23120541.00775-202000775-2020BronchUK: protocol for an observational cohort study and biobank in bronchiectasisAnthony De Soyza0Philip Mawson1Adam T. Hill2Stuart Elborn3Judy M. Bradley4Charles S. Haworth5R. Andres Floto6Robert Wilson7Michael R. Loebinger8Mary Carroll9Megan Crichton10James D. Chalmers11Anita Sullivan12Jeremy Brown13John R. Hurst14Jamie Duckers15Martin Kelly16John Steer17Tim Gatheral18Paul P. Walker19Craig Winstanley20Alistair McGuire21David Denning22Richard McNally23 Population and Health Science Institute, Newcastle University, National Institute of Health Research Biomedical Research Centre, Newcastle, UK Newcastle University, Newcastle, UK Royal Infirmary and University of Edinburgh, Edinburgh, UK The Wellcome–Wolfson Institute for Experimental Medicine, Queen's University Belfast, UK The Wellcome–Wolfson Institute for Experimental Medicine, Queen's University Belfast, UK Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK Host Defence Unit, Royal Brompton Hospital, Imperial College London, London, UK Host Defence Unit, Royal Brompton Hospital, Imperial College London, London, UK University Hospital Southampton NHS Foundation Trust, Southampton, UK College of Medicine, University of Dundee, Dundee, UK College of Medicine, University of Dundee, Dundee, UK Dept of Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK UCL Respiratory, University College London, London, UK UCL Respiratory, University College London, London, UK Cardiff and Vale University Health Board, Cardiff, UK Altnagelvin Area Hospital, Western Health and Social Care Trust, Londonderry, UK North Tyneside General Hospital, Northumbria Healthcare NHS Foundation Trust, North Shields, UK University Hospitals of Morecambe Bay NHS Foundation Trust, Morecambe, UK Liverpool University Hospitals, Liverpool, UK University of Liverpool, Liverpool, UK London School of Economics, London, UK The University of Manchester, Manchester, UK Newcastle University, Newcastle, UK Bronchiectasis has been a largely overlooked disease area in respiratory medicine. This is reflected by a shortage of large-scale studies and lack of approved therapies, in turn leading to a variation of treatment across centres. BronchUK (Bronchiectasis Observational Cohort and Biobank UK) is a multicentre, prospective, observational cohort study working collaboratively with the European Multicentre Bronchiectasis Audit and Research Collaboration project. The inclusion criteria for patients entering the study are a clinical history consistent with bronchiectasis and computed tomography demonstrating bronchiectasis. Main exclusion criteria are 1) patients unable to provide informed consent, 2) bronchiectasis due to known cystic fibrosis or where bronchiectasis is not the main or co-dominant respiratory disease, 3) age <18 years, and 4) prior lung transplantation for bronchiectasis. The study is aligned to standard UK National Health Service (NHS) practice with an aim to recruit a minimum of 1500 patients from across at least nine secondary care centres. Patient data collected at baseline includes demographics, aetiology testing, comorbidities, lung function, radiology, treatments, microbiology and quality of life. Patients are followed up annually for a maximum of 5 years and, where able, blood and/or sputa samples are collected and stored in a central biobank. BronchUK aims to collect robust longitudinal data that can be used for analysis into current NHS practice and patient outcomes, and to become an integral resource to better inform future interventional studies in bronchiectasis.http://openres.ersjournals.com/content/7/2/00775-2020.full |
| spellingShingle | Anthony De Soyza Philip Mawson Adam T. Hill Stuart Elborn Judy M. Bradley Charles S. Haworth R. Andres Floto Robert Wilson Michael R. Loebinger Mary Carroll Megan Crichton James D. Chalmers Anita Sullivan Jeremy Brown John R. Hurst Jamie Duckers Martin Kelly John Steer Tim Gatheral Paul P. Walker Craig Winstanley Alistair McGuire David Denning Richard McNally BronchUK: protocol for an observational cohort study and biobank in bronchiectasis ERJ Open Research |
| title | BronchUK: protocol for an observational cohort study and biobank in bronchiectasis |
| title_full | BronchUK: protocol for an observational cohort study and biobank in bronchiectasis |
| title_fullStr | BronchUK: protocol for an observational cohort study and biobank in bronchiectasis |
| title_full_unstemmed | BronchUK: protocol for an observational cohort study and biobank in bronchiectasis |
| title_short | BronchUK: protocol for an observational cohort study and biobank in bronchiectasis |
| title_sort | bronchuk protocol for an observational cohort study and biobank in bronchiectasis |
| url | http://openres.ersjournals.com/content/7/2/00775-2020.full |
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