The efficacy of ipidacrine in patients with diabetic polyneuropathy
Peripheral nervous system involvement in patients with type 2 diabetes mellitus is a severe complication associated with a decrease in the quality of life, the development of disability and lethal outcomes. The most negative in terms of prognosis is autonomic diabetic polyneuropathy (DPN).Objective:...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2022-06-01
|
| Series: | Неврология, нейропсихиатрия, психосоматика |
| Subjects: | |
| Online Access: | https://nnp.ima-press.net/nnp/article/view/1822 |
| _version_ | 1797876279966433280 |
|---|---|
| author | P. R. Kamchatnov E. R. Barantsevich A. V. Chugunov A. A. Kabanov B. A. Abusueva |
| author_facet | P. R. Kamchatnov E. R. Barantsevich A. V. Chugunov A. A. Kabanov B. A. Abusueva |
| author_sort | P. R. Kamchatnov |
| collection | DOAJ |
| description | Peripheral nervous system involvement in patients with type 2 diabetes mellitus is a severe complication associated with a decrease in the quality of life, the development of disability and lethal outcomes. The most negative in terms of prognosis is autonomic diabetic polyneuropathy (DPN).Objective: to study the effectiveness of the drug ipidacrine (Ipigrix) in patients with DPN.Patients and methods. 49 patients with DPN were observed, they were divided into three groups. Patients of the 1st group (n=16) received ipidacrine 20 mg orally 3 times a day for 60 days, patients of the 2nd group (n=17) received ipidacrine 15 mg 1 time per day intramuscularly for 15 days, then – 20 mg 3 times a day orally up to 2 months; patients of the 3rd group (n=16) received only basic therapy. The clinical condition, severity of pain syndrome according to the Neurological Symptoms Score (NSS), vegetative tests, and treatment tolerance were assessed.Results and discussion. The therapy was effective in terms of reducing the severity of neuropathic pain syndrome, as well as normalizing the results of vegetative tests. In patients of the 1st group, the total scores on the NSS scale decreased by 37% (p<0.05) by the 60th day of treatment. In patients of the 2nd group, the total scores on the NSS scale decreased by 22% by the 30th day (p<0.05) and by 35% (p<0.05) by the 60th day of treatment. A pronounced positive effect in terms of vegetative tests was noted on the 60th day of treatment in the 1st and 2nd groups of patients. No adverse events were observed during the treatment period in any of patients of the 1st and the 2nd groups. In the comparison group, there were no significant changes in scores on the NSS scale and indicators of vegetative samples.Conclusion. The effectiveness of the drug ipidacrine (Ipigrix) in patients with pain and vegetative manifestations of DPN was noted. |
| first_indexed | 2024-04-10T02:00:48Z |
| format | Article |
| id | doaj.art-546abfd59ad94ac4b94a1197110e8bc4 |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:00:48Z |
| publishDate | 2022-06-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-546abfd59ad94ac4b94a1197110e8bc42023-03-13T08:42:22ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422022-06-01143384310.14412/2074-2711-2022-3-38-431266The efficacy of ipidacrine in patients with diabetic polyneuropathyP. R. Kamchatnov0E. R. Barantsevich1A. V. Chugunov2A. A. Kabanov3B. A. Abusueva4N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaAcad. I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaDagestan State Medical University, Ministry of Health of RussiaPeripheral nervous system involvement in patients with type 2 diabetes mellitus is a severe complication associated with a decrease in the quality of life, the development of disability and lethal outcomes. The most negative in terms of prognosis is autonomic diabetic polyneuropathy (DPN).Objective: to study the effectiveness of the drug ipidacrine (Ipigrix) in patients with DPN.Patients and methods. 49 patients with DPN were observed, they were divided into three groups. Patients of the 1st group (n=16) received ipidacrine 20 mg orally 3 times a day for 60 days, patients of the 2nd group (n=17) received ipidacrine 15 mg 1 time per day intramuscularly for 15 days, then – 20 mg 3 times a day orally up to 2 months; patients of the 3rd group (n=16) received only basic therapy. The clinical condition, severity of pain syndrome according to the Neurological Symptoms Score (NSS), vegetative tests, and treatment tolerance were assessed.Results and discussion. The therapy was effective in terms of reducing the severity of neuropathic pain syndrome, as well as normalizing the results of vegetative tests. In patients of the 1st group, the total scores on the NSS scale decreased by 37% (p<0.05) by the 60th day of treatment. In patients of the 2nd group, the total scores on the NSS scale decreased by 22% by the 30th day (p<0.05) and by 35% (p<0.05) by the 60th day of treatment. A pronounced positive effect in terms of vegetative tests was noted on the 60th day of treatment in the 1st and 2nd groups of patients. No adverse events were observed during the treatment period in any of patients of the 1st and the 2nd groups. In the comparison group, there were no significant changes in scores on the NSS scale and indicators of vegetative samples.Conclusion. The effectiveness of the drug ipidacrine (Ipigrix) in patients with pain and vegetative manifestations of DPN was noted.https://nnp.ima-press.net/nnp/article/view/1822diabetic autonomic neuropathycardiac autonomic neuropathyheart rate variabilitydiagnosticstreatmentipidacrineipigrix |
| spellingShingle | P. R. Kamchatnov E. R. Barantsevich A. V. Chugunov A. A. Kabanov B. A. Abusueva The efficacy of ipidacrine in patients with diabetic polyneuropathy Неврология, нейропсихиатрия, психосоматика diabetic autonomic neuropathy cardiac autonomic neuropathy heart rate variability diagnostics treatment ipidacrine ipigrix |
| title | The efficacy of ipidacrine in patients with diabetic polyneuropathy |
| title_full | The efficacy of ipidacrine in patients with diabetic polyneuropathy |
| title_fullStr | The efficacy of ipidacrine in patients with diabetic polyneuropathy |
| title_full_unstemmed | The efficacy of ipidacrine in patients with diabetic polyneuropathy |
| title_short | The efficacy of ipidacrine in patients with diabetic polyneuropathy |
| title_sort | efficacy of ipidacrine in patients with diabetic polyneuropathy |
| topic | diabetic autonomic neuropathy cardiac autonomic neuropathy heart rate variability diagnostics treatment ipidacrine ipigrix |
| url | https://nnp.ima-press.net/nnp/article/view/1822 |
| work_keys_str_mv | AT prkamchatnov theefficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT erbarantsevich theefficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT avchugunov theefficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT aakabanov theefficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT baabusueva theefficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT prkamchatnov efficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT erbarantsevich efficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT avchugunov efficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT aakabanov efficacyofipidacrineinpatientswithdiabeticpolyneuropathy AT baabusueva efficacyofipidacrineinpatientswithdiabeticpolyneuropathy |