Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations of EV biogenesis, sorting, release and uptake i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/23/15317 |
| _version_ | 1797462999429021696 |
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| author | Rostyslav Horbay Ali Hamraghani Leonardo Ermini Sophie Holcik Shawn T. Beug Behzad Yeganeh |
| author_facet | Rostyslav Horbay Ali Hamraghani Leonardo Ermini Sophie Holcik Shawn T. Beug Behzad Yeganeh |
| author_sort | Rostyslav Horbay |
| collection | DOAJ |
| description | Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations of EV biogenesis, sorting, release and uptake is the basis of a number of disorders. In this review, we summarize recent advances of the complex roles of the sphingolipid ceramide and lysosomes in the journey of EV biogenesis to uptake. |
| first_indexed | 2024-03-09T17:44:27Z |
| format | Article |
| id | doaj.art-546b333bb41b4c5599fb2dfbb3d883a5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T17:44:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-546b333bb41b4c5599fb2dfbb3d883a52023-11-24T11:17:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123231531710.3390/ijms232315317Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and ReleaseRostyslav Horbay0Ali Hamraghani1Leonardo Ermini2Sophie Holcik3Shawn T. Beug4Behzad Yeganeh5Apoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, CanadaApoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, CanadaDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, ItalyApoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, CanadaApoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, CanadaApoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, CanadaCells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations of EV biogenesis, sorting, release and uptake is the basis of a number of disorders. In this review, we summarize recent advances of the complex roles of the sphingolipid ceramide and lysosomes in the journey of EV biogenesis to uptake.https://www.mdpi.com/1422-0067/23/23/15317exosomemultivesicular bodyintraluminal vesiclesmitochondria-derived vesicleESCRT-dependent pathwayESCRT-independent pathway |
| spellingShingle | Rostyslav Horbay Ali Hamraghani Leonardo Ermini Sophie Holcik Shawn T. Beug Behzad Yeganeh Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release International Journal of Molecular Sciences exosome multivesicular body intraluminal vesicles mitochondria-derived vesicle ESCRT-dependent pathway ESCRT-independent pathway |
| title | Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release |
| title_full | Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release |
| title_fullStr | Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release |
| title_full_unstemmed | Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release |
| title_short | Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release |
| title_sort | role of ceramides and lysosomes in extracellular vesicle biogenesis cargo sorting and release |
| topic | exosome multivesicular body intraluminal vesicles mitochondria-derived vesicle ESCRT-dependent pathway ESCRT-independent pathway |
| url | https://www.mdpi.com/1422-0067/23/23/15317 |
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