Drug Delivery Approaches for Managing Overactive Bladder (OAB): A Systematic Review
Overactive bladder syndrome (OAB) is characterised by urgency symptoms, with or without urgency incontinence, usually with frequency and nocturia and severely affects the quality of life. This systematic review evaluates the various drug delivery strategies used in practice to manage OAB. Advanced d...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/5/409 |
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| author | Zara Khizer Amina Sadia Raman Sharma Samia Farhaj Jorabar Singh Nirwan Pratibha G. Kakadia Talib Hussain Abid Mehmood Yousaf Yasser Shahzad Barbara R. Conway Muhammad Usman Ghori |
| author_facet | Zara Khizer Amina Sadia Raman Sharma Samia Farhaj Jorabar Singh Nirwan Pratibha G. Kakadia Talib Hussain Abid Mehmood Yousaf Yasser Shahzad Barbara R. Conway Muhammad Usman Ghori |
| author_sort | Zara Khizer |
| collection | DOAJ |
| description | Overactive bladder syndrome (OAB) is characterised by urgency symptoms, with or without urgency incontinence, usually with frequency and nocturia and severely affects the quality of life. This systematic review evaluates the various drug delivery strategies used in practice to manage OAB. Advanced drug delivery strategies alongside traditional strategies were comprehensively analysed and comparatively evaluated. The present review was conducted according to the preferred reporting items for systematic reviews and meta-analyses guidelines. A total of 24 studies reporting the development of novel formulations for the treatment of OAB were considered eligible and were further categorised according to the route of drug administration. The review found that various drug delivery routes (transdermal, intravesicular, oral, vaginal and intramuscular) are used for the administration of drugs for managing OAB, however, the outcomes illustrated the marked potential of transdermal drug delivery route. The findings of the current review are expected to be helpful for pharmaceutical scientists to better comprehend the existing literature and challenges and is anticipated to provide a basis for designing and fabricating novel drug delivery systems to manage OAB. |
| first_indexed | 2024-03-10T11:57:52Z |
| format | Article |
| id | doaj.art-546b58580fe6464fa925b6625d3ef80a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T11:57:52Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-546b58580fe6464fa925b6625d3ef80a2023-11-21T17:10:37ZengMDPI AGPharmaceuticals1424-82472021-04-0114540910.3390/ph14050409Drug Delivery Approaches for Managing Overactive Bladder (OAB): A Systematic ReviewZara Khizer0Amina Sadia1Raman Sharma2Samia Farhaj3Jorabar Singh Nirwan4Pratibha G. Kakadia5Talib Hussain6Abid Mehmood Yousaf7Yasser Shahzad8Barbara R. Conway9Muhammad Usman Ghori10Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UKDistrict Headquarter Hospital, Sahiwal 57000, PakistanParkside Medical Practice, Horton Park Health Centre, Bradford BD7 3EG, UKDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UKDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UKBehavioral & Social Science, Integrated Behavioral Health Research Institute, San Gabriel, CA 91775, USADepartment of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 45550, PakistanDepartment of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 45550, PakistanDepartment of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 45550, PakistanDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UKDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UKOveractive bladder syndrome (OAB) is characterised by urgency symptoms, with or without urgency incontinence, usually with frequency and nocturia and severely affects the quality of life. This systematic review evaluates the various drug delivery strategies used in practice to manage OAB. Advanced drug delivery strategies alongside traditional strategies were comprehensively analysed and comparatively evaluated. The present review was conducted according to the preferred reporting items for systematic reviews and meta-analyses guidelines. A total of 24 studies reporting the development of novel formulations for the treatment of OAB were considered eligible and were further categorised according to the route of drug administration. The review found that various drug delivery routes (transdermal, intravesicular, oral, vaginal and intramuscular) are used for the administration of drugs for managing OAB, however, the outcomes illustrated the marked potential of transdermal drug delivery route. The findings of the current review are expected to be helpful for pharmaceutical scientists to better comprehend the existing literature and challenges and is anticipated to provide a basis for designing and fabricating novel drug delivery systems to manage OAB.https://www.mdpi.com/1424-8247/14/5/409overactive bladderdrug deliverytransdermal drug deliverypharmacotherapyoral drug deliverysystematic review |
| spellingShingle | Zara Khizer Amina Sadia Raman Sharma Samia Farhaj Jorabar Singh Nirwan Pratibha G. Kakadia Talib Hussain Abid Mehmood Yousaf Yasser Shahzad Barbara R. Conway Muhammad Usman Ghori Drug Delivery Approaches for Managing Overactive Bladder (OAB): A Systematic Review Pharmaceuticals overactive bladder drug delivery transdermal drug delivery pharmacotherapy oral drug delivery systematic review |
| title | Drug Delivery Approaches for Managing Overactive Bladder (OAB): A Systematic Review |
| title_full | Drug Delivery Approaches for Managing Overactive Bladder (OAB): A Systematic Review |
| title_fullStr | Drug Delivery Approaches for Managing Overactive Bladder (OAB): A Systematic Review |
| title_full_unstemmed | Drug Delivery Approaches for Managing Overactive Bladder (OAB): A Systematic Review |
| title_short | Drug Delivery Approaches for Managing Overactive Bladder (OAB): A Systematic Review |
| title_sort | drug delivery approaches for managing overactive bladder oab a systematic review |
| topic | overactive bladder drug delivery transdermal drug delivery pharmacotherapy oral drug delivery systematic review |
| url | https://www.mdpi.com/1424-8247/14/5/409 |
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