Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review
Background: With promising outcomes, platelet-rich plasma (PRP) has recently been suggested as a treatment for olfactory dysfunction (OD). Methods: Clinical studies utilizing PRP in OD caused by COVID-19, trauma, anesthetic exposure, viral infection, and chronic rhinosinusitis were included in a sys...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/3/782 |
| _version_ | 1797318593872920576 |
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| author | Antonio Moffa Domiziana Nardelli Lucrezia Giorgi Simone Di Giovanni Luca Carnuccio Carmen Mangino Peter Baptista Michele Vacca Manuele Casale |
| author_facet | Antonio Moffa Domiziana Nardelli Lucrezia Giorgi Simone Di Giovanni Luca Carnuccio Carmen Mangino Peter Baptista Michele Vacca Manuele Casale |
| author_sort | Antonio Moffa |
| collection | DOAJ |
| description | Background: With promising outcomes, platelet-rich plasma (PRP) has recently been suggested as a treatment for olfactory dysfunction (OD). Methods: Clinical studies utilizing PRP in OD caused by COVID-19, trauma, anesthetic exposure, viral infection, and chronic rhinosinusitis were included in a systematic review. Results: Ten clinical studies were qualitatively analyzed. Six of these studies used the PRP for OD caused by COVID-19, one on OD after functional endoscopic sinus surgery, and three on post-infectious or post-trauma OD. The population included 531 patients, ranging in age from 15 to 63. Conclusion: The use of PRP may be a risk-free and efficient therapeutic option with very encouraging outcomes. Indeed, it enhances olfactory perception in patients who not only exhibit COVID-19 infection aftereffects, but also in those who have lost their sense of smell due to trauma, rhinosinusitis, rhinitis, or even surgery. To evaluate the PRP’s therapeutic benefits in OD patients and to compare the efficacy of different therapeutic protocols with regard to treatment schedules, there is an urgent need for focused controlled trials. |
| first_indexed | 2024-03-08T03:53:36Z |
| format | Article |
| id | doaj.art-546b9774ed814723b140691e3fdefe5c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T03:53:36Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-546b9774ed814723b140691e3fdefe5c2024-02-09T15:16:01ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113378210.3390/jcm13030782Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic ReviewAntonio Moffa0Domiziana Nardelli1Lucrezia Giorgi2Simone Di Giovanni3Luca Carnuccio4Carmen Mangino5Peter Baptista6Michele Vacca7Manuele Casale8Integrated Therapies in Otolaryngology, Fondazione Policlinico Università Campus Bio-Medico di Roma, 00128 Rome, ItalySchool of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyIntegrated Therapies in Otolaryngology, Fondazione Policlinico Università Campus Bio-Medico di Roma, 00128 Rome, ItalyIntegrated Therapies in Otolaryngology, Fondazione Policlinico Università Campus Bio-Medico di Roma, 00128 Rome, ItalySchool of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, ItalySchool of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyDepartment of Otorhinolaryngology, Clinica Universidad de Navarra, 31008 Pamplona, SpainTransfusion Medicine and Cell Therapy, Fondazione Policlinico Università Campus Bio-Medico di Roma, 00128 Rome, ItalyIntegrated Therapies in Otolaryngology, Fondazione Policlinico Università Campus Bio-Medico di Roma, 00128 Rome, ItalyBackground: With promising outcomes, platelet-rich plasma (PRP) has recently been suggested as a treatment for olfactory dysfunction (OD). Methods: Clinical studies utilizing PRP in OD caused by COVID-19, trauma, anesthetic exposure, viral infection, and chronic rhinosinusitis were included in a systematic review. Results: Ten clinical studies were qualitatively analyzed. Six of these studies used the PRP for OD caused by COVID-19, one on OD after functional endoscopic sinus surgery, and three on post-infectious or post-trauma OD. The population included 531 patients, ranging in age from 15 to 63. Conclusion: The use of PRP may be a risk-free and efficient therapeutic option with very encouraging outcomes. Indeed, it enhances olfactory perception in patients who not only exhibit COVID-19 infection aftereffects, but also in those who have lost their sense of smell due to trauma, rhinosinusitis, rhinitis, or even surgery. To evaluate the PRP’s therapeutic benefits in OD patients and to compare the efficacy of different therapeutic protocols with regard to treatment schedules, there is an urgent need for focused controlled trials.https://www.mdpi.com/2077-0383/13/3/782olfactory dysfunctionplatelet-rich plasmasmell lossanosmiaCOVID-19 |
| spellingShingle | Antonio Moffa Domiziana Nardelli Lucrezia Giorgi Simone Di Giovanni Luca Carnuccio Carmen Mangino Peter Baptista Michele Vacca Manuele Casale Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review Journal of Clinical Medicine olfactory dysfunction platelet-rich plasma smell loss anosmia COVID-19 |
| title | Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review |
| title_full | Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review |
| title_fullStr | Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review |
| title_full_unstemmed | Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review |
| title_short | Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review |
| title_sort | platelet rich plasma for patients with olfactory dysfunction myth or reality a systematic review |
| topic | olfactory dysfunction platelet-rich plasma smell loss anosmia COVID-19 |
| url | https://www.mdpi.com/2077-0383/13/3/782 |
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